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Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan
BACKGROUND: Central corneal thickness (CCT) can be measured by using contact and non-contact methods. Ultrasound pachymetry (US pachymetry) is a contact method for measuring CCT and is perhaps the most commonly used method. However, non-contact methods like scanning slit topography (Orbscan II), sli...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472076/ https://www.ncbi.nlm.nih.gov/pubmed/26109840 http://dx.doi.org/10.2147/OPTH.S81376 |
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author | Khaja, Wassia A Grover, Sandeep Kelmenson, Amy T Ferguson, Lee R Sambhav, Kumar Chalam, Kakarla V |
author_facet | Khaja, Wassia A Grover, Sandeep Kelmenson, Amy T Ferguson, Lee R Sambhav, Kumar Chalam, Kakarla V |
author_sort | Khaja, Wassia A |
collection | PubMed |
description | BACKGROUND: Central corneal thickness (CCT) can be measured by using contact and non-contact methods. Ultrasound pachymetry (US pachymetry) is a contact method for measuring CCT and is perhaps the most commonly used method. However, non-contact methods like scanning slit topography (Orbscan II), slit-lamp optical coherence tomography (SL-OCT), and specular microscopy are also used. Not many studies have correlated the measurement of CCT with all four modalities. The purpose of this study was to compare and correlate the CCT measurements obtained by US pachymetry with SL-OCT, specular microscopy, and Orbscan. METHOD: This is a prospective, comparative study done in an institutional setting. Thirty-two eyes of 32 subjects with no known ocular disease and best-corrected visual acuity of 20/20 were enrolled. CCT measurements were obtained using SL-OCT, specular microscopy, scanning slit topography (Orbscan), and US pachymetry. Three measurements were made with each instrument by the same operator. Mean, standard deviation, and coefficient of variation were calculated for CCT measurements acquired by the four measurement devices. Bland–Altman plot was constructed to determine the agreements between the CCT measurements obtained by different equipment. RESULTS: The mean CCT was 548.16±48.68 μm by US pachymetry. In comparison, CCT averaged 546.36±44.17 μm by SL-OCT, 557.61±49.92 μm by specular microscopy, and 551.03±48.96 μm by Orbscan for all subjects. Measurements by the various modalities were strongly correlated. Correlations (r(2)) of CCT, as measured by US pachymetry compared with other modalities, were: SL-OCT (r(2)=0.98, P<0.0001), specular microscopy (r(2)=0.98, P<0.0001), and Orbscan (r(2)=0.96, P<0.0001). All modalities had a linear correlation with US pachymetry measurements. CONCLUSION: In subjects with healthy corneas, SL-OCT, specular microscopy, and Orbscan (with correction factor) can be used interchangeably with US pachymetry in certain clinical settings. The four modalities showed significant linear correlations with one another. |
format | Online Article Text |
id | pubmed-4472076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44720762015-06-24 Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan Khaja, Wassia A Grover, Sandeep Kelmenson, Amy T Ferguson, Lee R Sambhav, Kumar Chalam, Kakarla V Clin Ophthalmol Original Research BACKGROUND: Central corneal thickness (CCT) can be measured by using contact and non-contact methods. Ultrasound pachymetry (US pachymetry) is a contact method for measuring CCT and is perhaps the most commonly used method. However, non-contact methods like scanning slit topography (Orbscan II), slit-lamp optical coherence tomography (SL-OCT), and specular microscopy are also used. Not many studies have correlated the measurement of CCT with all four modalities. The purpose of this study was to compare and correlate the CCT measurements obtained by US pachymetry with SL-OCT, specular microscopy, and Orbscan. METHOD: This is a prospective, comparative study done in an institutional setting. Thirty-two eyes of 32 subjects with no known ocular disease and best-corrected visual acuity of 20/20 were enrolled. CCT measurements were obtained using SL-OCT, specular microscopy, scanning slit topography (Orbscan), and US pachymetry. Three measurements were made with each instrument by the same operator. Mean, standard deviation, and coefficient of variation were calculated for CCT measurements acquired by the four measurement devices. Bland–Altman plot was constructed to determine the agreements between the CCT measurements obtained by different equipment. RESULTS: The mean CCT was 548.16±48.68 μm by US pachymetry. In comparison, CCT averaged 546.36±44.17 μm by SL-OCT, 557.61±49.92 μm by specular microscopy, and 551.03±48.96 μm by Orbscan for all subjects. Measurements by the various modalities were strongly correlated. Correlations (r(2)) of CCT, as measured by US pachymetry compared with other modalities, were: SL-OCT (r(2)=0.98, P<0.0001), specular microscopy (r(2)=0.98, P<0.0001), and Orbscan (r(2)=0.96, P<0.0001). All modalities had a linear correlation with US pachymetry measurements. CONCLUSION: In subjects with healthy corneas, SL-OCT, specular microscopy, and Orbscan (with correction factor) can be used interchangeably with US pachymetry in certain clinical settings. The four modalities showed significant linear correlations with one another. Dove Medical Press 2015-06-12 /pmc/articles/PMC4472076/ /pubmed/26109840 http://dx.doi.org/10.2147/OPTH.S81376 Text en © 2015 Khaja et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Khaja, Wassia A Grover, Sandeep Kelmenson, Amy T Ferguson, Lee R Sambhav, Kumar Chalam, Kakarla V Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan |
title | Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan |
title_full | Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan |
title_fullStr | Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan |
title_full_unstemmed | Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan |
title_short | Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan |
title_sort | comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and orbscan |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472076/ https://www.ncbi.nlm.nih.gov/pubmed/26109840 http://dx.doi.org/10.2147/OPTH.S81376 |
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