Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease

Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson’s disease (PD). To elucidate molecular mechanisms underlying neuronal dysfunction and alpha-synuclein pathology in the premotor phase of PD, we investigated the transcriptome of the substantia nigra (SN)...

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Detalles Bibliográficos
Autores principales: Dijkstra, Anke A., Ingrassia, Angela, de Menezes, Renee X., van Kesteren, Ronald E., Rozemuller, Annemieke J. M., Heutink, Peter, van de Berg, Wilma D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472235/
https://www.ncbi.nlm.nih.gov/pubmed/26087293
http://dx.doi.org/10.1371/journal.pone.0128651

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