The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

BACKGROUND: Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of cancer. Methylsulfonylmethane (MSM) is an organic sulfur compound shown to act against tumor cells. Tamoxifen is a commercially av...

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Detalles Bibliográficos
Autores principales: SP, Nipin, Darvin, Pramod, Yoo, Young Beom, Joung, Youn Hee, Kang, Dong Young, Kim, Don Nam, Hwang, Tae Sook, Kim, Sang Yoon, Kim, Wan Seop, Lee, Hak Kyo, Cho, Byung Wook, Kim, Heui Soo, Park, Kyung Do, Park, Jong Hwan, Chang, Soung Hoon, Yang, Young Mok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472404/
https://www.ncbi.nlm.nih.gov/pubmed/26084564
http://dx.doi.org/10.1186/s12885-015-1445-0

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