Non-toxic antimicrobials that evade drug resistance

Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. But this benefit often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded resistance for more than half a cen...

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Detalles Bibliográficos
Autores principales: Davis, Stephen A., Vincent, Benjamin M., Endo, Matthew M., Whitesell, Luke, Marchillo, Karen, Andes, David R., Lindquist, Susan, Burke, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472574/
https://www.ncbi.nlm.nih.gov/pubmed/26030729
http://dx.doi.org/10.1038/nchembio.1821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472574/
https://www.ncbi.nlm.nih.gov/pubmed/26030729
http://dx.doi.org/10.1038/nchembio.1821

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