Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue

O-6-methylguanine-DNA methyltransferase (MGMT) has been associated with resistance to alkylating agent cancer therapy in Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults. Lower expression or silencing of the MGMT protein by promoter methylation has been reported to im...

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Detalles Bibliográficos
Autores principales: de Abreu, Francine B., Gallagher, Torrey L., Liu, Emmeline Z., Tsongalis, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472848/
https://www.ncbi.nlm.nih.gov/pubmed/26150933
http://dx.doi.org/10.1016/j.mex.2014.06.001

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