Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide...

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Detalles Bibliográficos
Autores principales: Smallie, Tim, Ross, Ewan A., Ammit, Alaina J., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Ridley, Michael L., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2015
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472943/
https://www.ncbi.nlm.nih.gov/pubmed/26019272
http://dx.doi.org/10.4049/jimmunol.1402830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472943/
https://www.ncbi.nlm.nih.gov/pubmed/26019272
http://dx.doi.org/10.4049/jimmunol.1402830

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