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MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Na(v)1.5 sodium channels
The transmembrane S6 segments of Na(+) sodium channels form the cytoplasmic entrance of the channel and line the internal aspects of the aqueous pore. This region of the channel has been implicated in Na(+) channel permeation, gating, and pharmacology. In this study we utilized cysteine substitution...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472985/ https://www.ncbi.nlm.nih.gov/pubmed/26150789 http://dx.doi.org/10.3389/fphar.2015.00118 |