Cargando…

Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)

BACKGROUND: To develop an OSTAi tool and compare this with the National Osteoporosis Foundation recommendations in 2013 (NOF 2013) for bone mineral density (BMD) testing among Taiwan postmenopausal women. METHODS: Taiwan Osteoporosis Association (TOA) conducted a nationwide BMD survey by a bus insta...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Fu-Mei, Liu, Dung-Huan, Chen, Jia-Feng, Yu, Shan-Fu, Chiu, Wen-Chan, Hsu, Chung-Yuan, Ko, Chi-Hua, Tsai, Ching-Chou, Cheng, Tien-Tsai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473006/
https://www.ncbi.nlm.nih.gov/pubmed/26086766
http://dx.doi.org/10.1371/journal.pone.0130716
_version_ 1782377165648560128
author Su, Fu-Mei
Liu, Dung-Huan
Chen, Jia-Feng
Yu, Shan-Fu
Chiu, Wen-Chan
Hsu, Chung-Yuan
Ko, Chi-Hua
Tsai, Ching-Chou
Cheng, Tien-Tsai
author_facet Su, Fu-Mei
Liu, Dung-Huan
Chen, Jia-Feng
Yu, Shan-Fu
Chiu, Wen-Chan
Hsu, Chung-Yuan
Ko, Chi-Hua
Tsai, Ching-Chou
Cheng, Tien-Tsai
author_sort Su, Fu-Mei
collection PubMed
description BACKGROUND: To develop an OSTAi tool and compare this with the National Osteoporosis Foundation recommendations in 2013 (NOF 2013) for bone mineral density (BMD) testing among Taiwan postmenopausal women. METHODS: Taiwan Osteoporosis Association (TOA) conducted a nationwide BMD survey by a bus installed with a dual energy X-ray absorptiometry (DXA) between 2008 and 2011. All of the participants completed questionnaire, which included demographics and risk factors of osteoporotic fracture in FRAX tool. We used the database to analyze potential risk factors for osteoporosis and followed the model by Koh et al. to develop a risk index via multiple variable regression analysis and item reduction. We used the index values to set up a simple algorithm (namely OSTAi) to identify those who need BMD measurement. Receiver operating characteristic (ROC) curve and the area under the curve (AUC) was used to compare the sensitivity/specificity analysis of this model with that of recommendations by NOF 2013. RESULTS: A total of 12,175 Taiwan postmenopausal women enrolled in this survey. The index value was derived by age and body weight of the participants according to weighted odds of each risk factor and the selected cutoff value was set at “-1”. There are 6393 (52.5%) participants whose index value is below “-1” and whose risk of osteoporosis was 57.5% (3674/6393). The AUC for OSTAi and NOF 2013 were 0.739 (95% confidence interval (CI), 0.728–0.749, P<0.001) and 0.618 (95% CI, 0.606–0.630, P<0.001), respectively. The sensitivity and specificity of OSTAi, at the selected cutoff value of -1, and NOF 2013 to identify osteoporosis were 73.1%, 62.0% and 78.3%, 45.7%, respectively. CONCLUSIONS: As OSTA for Asian populations, OSTAi is an useful tool to identify Taiwan postmenopausal women with osteoporosis, In comparison with NOF 2013, OSTAi may be an easier and better tool for referral to BMD measurement by DXA in this area.
format Online
Article
Text
id pubmed-4473006
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-44730062015-06-29 Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS) Su, Fu-Mei Liu, Dung-Huan Chen, Jia-Feng Yu, Shan-Fu Chiu, Wen-Chan Hsu, Chung-Yuan Ko, Chi-Hua Tsai, Ching-Chou Cheng, Tien-Tsai PLoS One Research Article BACKGROUND: To develop an OSTAi tool and compare this with the National Osteoporosis Foundation recommendations in 2013 (NOF 2013) for bone mineral density (BMD) testing among Taiwan postmenopausal women. METHODS: Taiwan Osteoporosis Association (TOA) conducted a nationwide BMD survey by a bus installed with a dual energy X-ray absorptiometry (DXA) between 2008 and 2011. All of the participants completed questionnaire, which included demographics and risk factors of osteoporotic fracture in FRAX tool. We used the database to analyze potential risk factors for osteoporosis and followed the model by Koh et al. to develop a risk index via multiple variable regression analysis and item reduction. We used the index values to set up a simple algorithm (namely OSTAi) to identify those who need BMD measurement. Receiver operating characteristic (ROC) curve and the area under the curve (AUC) was used to compare the sensitivity/specificity analysis of this model with that of recommendations by NOF 2013. RESULTS: A total of 12,175 Taiwan postmenopausal women enrolled in this survey. The index value was derived by age and body weight of the participants according to weighted odds of each risk factor and the selected cutoff value was set at “-1”. There are 6393 (52.5%) participants whose index value is below “-1” and whose risk of osteoporosis was 57.5% (3674/6393). The AUC for OSTAi and NOF 2013 were 0.739 (95% confidence interval (CI), 0.728–0.749, P<0.001) and 0.618 (95% CI, 0.606–0.630, P<0.001), respectively. The sensitivity and specificity of OSTAi, at the selected cutoff value of -1, and NOF 2013 to identify osteoporosis were 73.1%, 62.0% and 78.3%, 45.7%, respectively. CONCLUSIONS: As OSTA for Asian populations, OSTAi is an useful tool to identify Taiwan postmenopausal women with osteoporosis, In comparison with NOF 2013, OSTAi may be an easier and better tool for referral to BMD measurement by DXA in this area. Public Library of Science 2015-06-18 /pmc/articles/PMC4473006/ /pubmed/26086766 http://dx.doi.org/10.1371/journal.pone.0130716 Text en © 2015 Su et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Su, Fu-Mei
Liu, Dung-Huan
Chen, Jia-Feng
Yu, Shan-Fu
Chiu, Wen-Chan
Hsu, Chung-Yuan
Ko, Chi-Hua
Tsai, Ching-Chou
Cheng, Tien-Tsai
Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)
title Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)
title_full Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)
title_fullStr Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)
title_full_unstemmed Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)
title_short Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)
title_sort development and validation of an osteoporosis self-assessment tool for taiwan (ostai) postmenopausal women-a sub-study of the taiwan osteoporosis survey (tops)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473006/
https://www.ncbi.nlm.nih.gov/pubmed/26086766
http://dx.doi.org/10.1371/journal.pone.0130716
work_keys_str_mv AT sufumei developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT liudunghuan developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT chenjiafeng developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT yushanfu developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT chiuwenchan developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT hsuchungyuan developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT kochihua developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT tsaichingchou developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops
AT chengtientsai developmentandvalidationofanosteoporosisselfassessmenttoolfortaiwanostaipostmenopausalwomenasubstudyofthetaiwanosteoporosissurveytops