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Using linkage maps to correct and scaffold de novo genome assemblies: methods, challenges, and computational tools
Modern high-throughput DNA sequencing has made it possible to inexpensively produce genome sequences, but in practice many of these draft genomes are fragmented and incomplete. Genetic linkage maps based on recombination rates between physical markers have been used in biology for over 100 years and...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473057/ https://www.ncbi.nlm.nih.gov/pubmed/26150829 http://dx.doi.org/10.3389/fgene.2015.00220 |