Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis

The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG,...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Lihong, Zhang, Jinhua, Xiao, Shiji, Huang, Jinlong, Zhang, Yuanyuan, Shen, Jianzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473094/
https://www.ncbi.nlm.nih.gov/pubmed/26106580
http://dx.doi.org/10.1016/j.mgene.2015.05.003
_version_ 1782377182319869952
author Tian, Lihong
Zhang, Jinhua
Xiao, Shiji
Huang, Jinlong
Zhang, Yuanyuan
Shen, Jianzhen
author_facet Tian, Lihong
Zhang, Jinhua
Xiao, Shiji
Huang, Jinlong
Zhang, Yuanyuan
Shen, Jianzhen
author_sort Tian, Lihong
collection PubMed
description The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant differences on mean daily warfarin dose (MDWD). This meta-analysis was the first to report the relationship between GGCX SNPs and MDWD in Chinese populations. No evidence could be found in the relationship between SNPs of GGCX (rs699664 and rs12714145) and maintenance warfarin dose.
format Online
Article
Text
id pubmed-4473094
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-44730942015-06-23 Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis Tian, Lihong Zhang, Jinhua Xiao, Shiji Huang, Jinlong Zhang, Yuanyuan Shen, Jianzhen Meta Gene Article The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant differences on mean daily warfarin dose (MDWD). This meta-analysis was the first to report the relationship between GGCX SNPs and MDWD in Chinese populations. No evidence could be found in the relationship between SNPs of GGCX (rs699664 and rs12714145) and maintenance warfarin dose. Elsevier 2015-06-05 /pmc/articles/PMC4473094/ /pubmed/26106580 http://dx.doi.org/10.1016/j.mgene.2015.05.003 Text en © 2015 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tian, Lihong
Zhang, Jinhua
Xiao, Shiji
Huang, Jinlong
Zhang, Yuanyuan
Shen, Jianzhen
Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis
title Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis
title_full Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis
title_fullStr Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis
title_full_unstemmed Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis
title_short Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis
title_sort impact of polymorphisms of the ggcx gene on maintenance warfarin dose in chinese populations: systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473094/
https://www.ncbi.nlm.nih.gov/pubmed/26106580
http://dx.doi.org/10.1016/j.mgene.2015.05.003
work_keys_str_mv AT tianlihong impactofpolymorphismsoftheggcxgeneonmaintenancewarfarindoseinchinesepopulationssystematicreviewandmetaanalysis
AT zhangjinhua impactofpolymorphismsoftheggcxgeneonmaintenancewarfarindoseinchinesepopulationssystematicreviewandmetaanalysis
AT xiaoshiji impactofpolymorphismsoftheggcxgeneonmaintenancewarfarindoseinchinesepopulationssystematicreviewandmetaanalysis
AT huangjinlong impactofpolymorphismsoftheggcxgeneonmaintenancewarfarindoseinchinesepopulationssystematicreviewandmetaanalysis
AT zhangyuanyuan impactofpolymorphismsoftheggcxgeneonmaintenancewarfarindoseinchinesepopulationssystematicreviewandmetaanalysis
AT shenjianzhen impactofpolymorphismsoftheggcxgeneonmaintenancewarfarindoseinchinesepopulationssystematicreviewandmetaanalysis

Ejemplares similares