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Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study

The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lv...

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Autores principales: Brambati, Simona Maria, Amici, Serena, Racine, Caroline A., Neuhaus, John, Miller, Zachary, Ogar, Jenny, Dronkers, Nina, Miller, Bruce L., Rosen, Howard, Gorno-Tempini, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473099/
https://www.ncbi.nlm.nih.gov/pubmed/26106560
http://dx.doi.org/10.1016/j.nicl.2015.01.011
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author Brambati, Simona Maria
Amici, Serena
Racine, Caroline A.
Neuhaus, John
Miller, Zachary
Ogar, Jenny
Dronkers, Nina
Miller, Bruce L.
Rosen, Howard
Gorno-Tempini, Maria Luisa
author_facet Brambati, Simona Maria
Amici, Serena
Racine, Caroline A.
Neuhaus, John
Miller, Zachary
Ogar, Jenny
Dronkers, Nina
Miller, Bruce L.
Rosen, Howard
Gorno-Tempini, Maria Luisa
author_sort Brambati, Simona Maria
collection PubMed
description The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.
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spelling pubmed-44730992015-06-23 Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study Brambati, Simona Maria Amici, Serena Racine, Caroline A. Neuhaus, John Miller, Zachary Ogar, Jenny Dronkers, Nina Miller, Bruce L. Rosen, Howard Gorno-Tempini, Maria Luisa Neuroimage Clin Article The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression. Elsevier 2015-01-22 /pmc/articles/PMC4473099/ /pubmed/26106560 http://dx.doi.org/10.1016/j.nicl.2015.01.011 Text en © 2015 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Brambati, Simona Maria
Amici, Serena
Racine, Caroline A.
Neuhaus, John
Miller, Zachary
Ogar, Jenny
Dronkers, Nina
Miller, Bruce L.
Rosen, Howard
Gorno-Tempini, Maria Luisa
Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study
title Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study
title_full Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study
title_fullStr Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study
title_full_unstemmed Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study
title_short Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study
title_sort longitudinal gray matter contraction in three variants of primary progressive aphasia: a tenser-based morphometry study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473099/
https://www.ncbi.nlm.nih.gov/pubmed/26106560
http://dx.doi.org/10.1016/j.nicl.2015.01.011
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