Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals

We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials...

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Autores principales: Naggie, Susanna, Patel, Keyur, Yang, Lan-Yan, Chow, Shein-Chung, Johnson, Victoria, Guyton, John R., Muir, Andrew J., Sulkowski, Mark, Hicks, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473112/
https://www.ncbi.nlm.nih.gov/pubmed/26110167
http://dx.doi.org/10.1093/ofid/ofv066
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author Naggie, Susanna
Patel, Keyur
Yang, Lan-Yan
Chow, Shein-Chung
Johnson, Victoria
Guyton, John R.
Muir, Andrew J.
Sulkowski, Mark
Hicks, Charles
author_facet Naggie, Susanna
Patel, Keyur
Yang, Lan-Yan
Chow, Shein-Chung
Johnson, Victoria
Guyton, John R.
Muir, Andrew J.
Sulkowski, Mark
Hicks, Charles
author_sort Naggie, Susanna
collection PubMed
description We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log(10) HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.
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spelling pubmed-44731122015-06-24 Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals Naggie, Susanna Patel, Keyur Yang, Lan-Yan Chow, Shein-Chung Johnson, Victoria Guyton, John R. Muir, Andrew J. Sulkowski, Mark Hicks, Charles Open Forum Infect Dis Brief Reports We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log(10) HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients. Oxford University Press 2015-05-12 /pmc/articles/PMC4473112/ /pubmed/26110167 http://dx.doi.org/10.1093/ofid/ofv066 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Naggie, Susanna
Patel, Keyur
Yang, Lan-Yan
Chow, Shein-Chung
Johnson, Victoria
Guyton, John R.
Muir, Andrew J.
Sulkowski, Mark
Hicks, Charles
Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals
title Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals
title_full Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals
title_fullStr Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals
title_full_unstemmed Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals
title_short Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals
title_sort antiretroviral effects on host lipoproteins are associated with changes in hepatitis c virus (hcv) rna levels in human immunodeficiency virus/hcv coinfected individuals
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473112/
https://www.ncbi.nlm.nih.gov/pubmed/26110167
http://dx.doi.org/10.1093/ofid/ofv066
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