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Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats

The role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a hig...

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Autores principales: Paßlack, Nadine, Burmeier, Hannes, Brenten, Thomas, Neumann, Konrad, Zentek, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473174/
https://www.ncbi.nlm.nih.gov/pubmed/26101619
http://dx.doi.org/10.1017/jns.2014.13
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author Paßlack, Nadine
Burmeier, Hannes
Brenten, Thomas
Neumann, Konrad
Zentek, Jürgen
author_facet Paßlack, Nadine
Burmeier, Hannes
Brenten, Thomas
Neumann, Konrad
Zentek, Jürgen
author_sort Paßlack, Nadine
collection PubMed
description The role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a high protein quality (10–11 % greaves meal/diet) and a varying crude protein (CP) concentration (35, 44 and 57 % in DM) were compared. Additionally, the 57 % CP diet was compared with a fourth diet that had a similar CP concentration (55 % in DM), but a lower protein quality (34 % greaves meal/diet). The Ca and oxalate (Ox) concentrations were similar in all diets. A group of eight cats received the same diet at the same time. Each feeding period was divided into a 21 d adaptation period and a 7 d sampling period to collect urine. There were increases in urinary volume, urinary Ca concentrations, renal Ca and Ox excretion and urinary relative supersaturation (RSS) with CaOx with increasing dietary protein concentrations. Urinary pH ranged between 6·34 and 6·66 among all groups, with no unidirectional effect of dietary protein. Lower renal Ca excretion was observed when feeding the diet with the lower protein quality, however, the underlying mechanism needs further evaluation. In conclusion, although the observed higher urinary volume is beneficial, the increase in urinary Ca concentrations, renal Ca and Ox excretion and urinary RSS CaOx associated with a high-protein diet may be critical for the development of CaOx uroliths in cats.
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spelling pubmed-44731742015-06-22 Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats Paßlack, Nadine Burmeier, Hannes Brenten, Thomas Neumann, Konrad Zentek, Jürgen J Nutr Sci Metabolism and Metabolic Studies The role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a high protein quality (10–11 % greaves meal/diet) and a varying crude protein (CP) concentration (35, 44 and 57 % in DM) were compared. Additionally, the 57 % CP diet was compared with a fourth diet that had a similar CP concentration (55 % in DM), but a lower protein quality (34 % greaves meal/diet). The Ca and oxalate (Ox) concentrations were similar in all diets. A group of eight cats received the same diet at the same time. Each feeding period was divided into a 21 d adaptation period and a 7 d sampling period to collect urine. There were increases in urinary volume, urinary Ca concentrations, renal Ca and Ox excretion and urinary relative supersaturation (RSS) with CaOx with increasing dietary protein concentrations. Urinary pH ranged between 6·34 and 6·66 among all groups, with no unidirectional effect of dietary protein. Lower renal Ca excretion was observed when feeding the diet with the lower protein quality, however, the underlying mechanism needs further evaluation. In conclusion, although the observed higher urinary volume is beneficial, the increase in urinary Ca concentrations, renal Ca and Ox excretion and urinary RSS CaOx associated with a high-protein diet may be critical for the development of CaOx uroliths in cats. Cambridge University Press 2014-11-07 /pmc/articles/PMC4473174/ /pubmed/26101619 http://dx.doi.org/10.1017/jns.2014.13 Text en © The Author(s) 2014 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license <http://creativecommons.org/licenses/by/3.0/.
spellingShingle Metabolism and Metabolic Studies
Paßlack, Nadine
Burmeier, Hannes
Brenten, Thomas
Neumann, Konrad
Zentek, Jürgen
Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
title Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
title_full Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
title_fullStr Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
title_full_unstemmed Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
title_short Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
title_sort relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
topic Metabolism and Metabolic Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473174/
https://www.ncbi.nlm.nih.gov/pubmed/26101619
http://dx.doi.org/10.1017/jns.2014.13
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