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Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network...

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Autores principales: New, Anneliese B., Robin, Donald A., Parkinson, Amy L., Duffy, Joseph R., McNeil, Malcom R., Piguet, Olivier, Hornberger, Michael, Price, Cathy J., Eickhoff, Simon B., Ballard, Kirrie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473263/
https://www.ncbi.nlm.nih.gov/pubmed/26106568
http://dx.doi.org/10.1016/j.nicl.2015.03.013
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author New, Anneliese B.
Robin, Donald A.
Parkinson, Amy L.
Duffy, Joseph R.
McNeil, Malcom R.
Piguet, Olivier
Hornberger, Michael
Price, Cathy J.
Eickhoff, Simon B.
Ballard, Kirrie J.
author_facet New, Anneliese B.
Robin, Donald A.
Parkinson, Amy L.
Duffy, Joseph R.
McNeil, Malcom R.
Piguet, Olivier
Hornberger, Michael
Price, Cathy J.
Eickhoff, Simon B.
Ballard, Kirrie J.
author_sort New, Anneliese B.
collection PubMed
description Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.
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spelling pubmed-44732632015-06-23 Altered resting-state network connectivity in stroke patients with and without apraxia of speech New, Anneliese B. Robin, Donald A. Parkinson, Amy L. Duffy, Joseph R. McNeil, Malcom R. Piguet, Olivier Hornberger, Michael Price, Cathy J. Eickhoff, Simon B. Ballard, Kirrie J. Neuroimage Clin Article Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke. Elsevier 2015-03-25 /pmc/articles/PMC4473263/ /pubmed/26106568 http://dx.doi.org/10.1016/j.nicl.2015.03.013 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
New, Anneliese B.
Robin, Donald A.
Parkinson, Amy L.
Duffy, Joseph R.
McNeil, Malcom R.
Piguet, Olivier
Hornberger, Michael
Price, Cathy J.
Eickhoff, Simon B.
Ballard, Kirrie J.
Altered resting-state network connectivity in stroke patients with and without apraxia of speech
title Altered resting-state network connectivity in stroke patients with and without apraxia of speech
title_full Altered resting-state network connectivity in stroke patients with and without apraxia of speech
title_fullStr Altered resting-state network connectivity in stroke patients with and without apraxia of speech
title_full_unstemmed Altered resting-state network connectivity in stroke patients with and without apraxia of speech
title_short Altered resting-state network connectivity in stroke patients with and without apraxia of speech
title_sort altered resting-state network connectivity in stroke patients with and without apraxia of speech
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473263/
https://www.ncbi.nlm.nih.gov/pubmed/26106568
http://dx.doi.org/10.1016/j.nicl.2015.03.013
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