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Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population
Individuals with psychopathy possess emotional and behavioral abnormalities. Two neural regions, involved in behavioral control and emotion regulation, are often implicated: amygdala and ventromedial prefrontal cortex (VMPFC). Recently, in studies using adult criminal populations, reductions in micr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473285/ https://www.ncbi.nlm.nih.gov/pubmed/26106525 http://dx.doi.org/10.1016/j.nicl.2015.03.012 |
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author | Sobhani, Mona Baker, Laura Martins, Bradford Tuvblad, Catherine Aziz-Zadeh, Lisa |
author_facet | Sobhani, Mona Baker, Laura Martins, Bradford Tuvblad, Catherine Aziz-Zadeh, Lisa |
author_sort | Sobhani, Mona |
collection | PubMed |
description | Individuals with psychopathy possess emotional and behavioral abnormalities. Two neural regions, involved in behavioral control and emotion regulation, are often implicated: amygdala and ventromedial prefrontal cortex (VMPFC). Recently, in studies using adult criminal populations, reductions in microstructural integrity of the white matter connections (i.e., uncinate fasciculus (UF)) between these two neural regions have been discovered in criminals with psychopathy, supporting the notion of neural dysfunction in the amygdala–VMPFC circuit. Here, a young adult, community sample is used to assess whether psychopathic traits modulate microstructural integrity of UF, and whether this relationship is dependent upon levels of trait anxiety, which is sometimes used to distinguish subtypes of psychopathy. Results reveal a negative association between psychopathic traits and microstructural integrity of UF, supporting previous findings. However, no moderation of the relationship by trait anxiety was discovered. Findings provide further support for the notion of altered amygdala–VMPFC connectivity in association with higher psychopathic traits. |
format | Online Article Text |
id | pubmed-4473285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-44732852015-06-23 Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population Sobhani, Mona Baker, Laura Martins, Bradford Tuvblad, Catherine Aziz-Zadeh, Lisa Neuroimage Clin Article Individuals with psychopathy possess emotional and behavioral abnormalities. Two neural regions, involved in behavioral control and emotion regulation, are often implicated: amygdala and ventromedial prefrontal cortex (VMPFC). Recently, in studies using adult criminal populations, reductions in microstructural integrity of the white matter connections (i.e., uncinate fasciculus (UF)) between these two neural regions have been discovered in criminals with psychopathy, supporting the notion of neural dysfunction in the amygdala–VMPFC circuit. Here, a young adult, community sample is used to assess whether psychopathic traits modulate microstructural integrity of UF, and whether this relationship is dependent upon levels of trait anxiety, which is sometimes used to distinguish subtypes of psychopathy. Results reveal a negative association between psychopathic traits and microstructural integrity of UF, supporting previous findings. However, no moderation of the relationship by trait anxiety was discovered. Findings provide further support for the notion of altered amygdala–VMPFC connectivity in association with higher psychopathic traits. Elsevier 2015-03-27 /pmc/articles/PMC4473285/ /pubmed/26106525 http://dx.doi.org/10.1016/j.nicl.2015.03.012 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Sobhani, Mona Baker, Laura Martins, Bradford Tuvblad, Catherine Aziz-Zadeh, Lisa Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
title | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
title_full | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
title_fullStr | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
title_full_unstemmed | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
title_short | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
title_sort | psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473285/ https://www.ncbi.nlm.nih.gov/pubmed/26106525 http://dx.doi.org/10.1016/j.nicl.2015.03.012 |
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