Cargando…
Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism
Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hor...
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473605/ https://www.ncbi.nlm.nih.gov/pubmed/26089239 http://dx.doi.org/10.1038/srep11525 |
| _version_ | 1782377216723648512 |
|---|---|
| author | Jansen, S. W. Akintola, A. A. Roelfsema, F. van der Spoel, E. Cobbaert, C. M. Ballieux, B. E. Egri, P. Kvarta-Papp, Z. Gereben, B. Fekete, C. Slagboom, P. E. van der Grond, J. Demeneix, B. A. Pijl, H. Westendorp, R. G. J. van Heemst, D. |
| author_facet | Jansen, S. W. Akintola, A. A. Roelfsema, F. van der Spoel, E. Cobbaert, C. M. Ballieux, B. E. Egri, P. Kvarta-Papp, Z. Gereben, B. Fekete, C. Slagboom, P. E. van der Grond, J. Demeneix, B. A. Pijl, H. Westendorp, R. G. J. van Heemst, D. |
| author_sort | Jansen, S. W. |
| collection | PubMed |
| description | Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism. |
| format | Online Article Text |
| id | pubmed-4473605 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44736052015-07-13 Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism Jansen, S. W. Akintola, A. A. Roelfsema, F. van der Spoel, E. Cobbaert, C. M. Ballieux, B. E. Egri, P. Kvarta-Papp, Z. Gereben, B. Fekete, C. Slagboom, P. E. van der Grond, J. Demeneix, B. A. Pijl, H. Westendorp, R. G. J. van Heemst, D. Sci Rep Article Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism. Nature Publishing Group 2015-06-19 /pmc/articles/PMC4473605/ /pubmed/26089239 http://dx.doi.org/10.1038/srep11525 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Jansen, S. W. Akintola, A. A. Roelfsema, F. van der Spoel, E. Cobbaert, C. M. Ballieux, B. E. Egri, P. Kvarta-Papp, Z. Gereben, B. Fekete, C. Slagboom, P. E. van der Grond, J. Demeneix, B. A. Pijl, H. Westendorp, R. G. J. van Heemst, D. Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| title | Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| title_full | Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| title_fullStr | Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| title_full_unstemmed | Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| title_short | Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| title_sort | human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473605/ https://www.ncbi.nlm.nih.gov/pubmed/26089239 http://dx.doi.org/10.1038/srep11525 |
| work_keys_str_mv | AT jansensw humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT akintolaaa humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT roelfsemaf humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT vanderspoele humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT cobbaertcm humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT ballieuxbe humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT egrip humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT kvartapappz humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT gerebenb humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT feketec humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT slagboompe humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT vandergrondj humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT demeneixba humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT pijlh humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT westendorprgj humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism AT vanheemstd humanlongevityischaracterisedbyhighthyroidstimulatinghormonesecretionwithoutalteredenergymetabolism |