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Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice

BACE1 initiates amyloid-β (Aβ) generation and the resultant cerebral amyloidosis, as a characteristic of Alzheimer’s disease (AD). Thus, inhibition of BACE1 has been the focus of a large body of research. The most recent clinical trials highlight the difficulty involved in this type of anti-AD thera...

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Detalles Bibliográficos
Autores principales:	Li, Song, Hou, Huayan, Mori, Takashi, Sawmiller, Darrell, Smith, Adam, Tian, Jun, Wang, Yanjiang, Giunta, Brian, Sanberg, Paul R., Zhang, Sheqing, Tan, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473678/ https://www.ncbi.nlm.nih.gov/pubmed/26091071 http://dx.doi.org/10.1038/srep11322

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