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Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model
The orexigenic hormone ghrelin, a potential antagonist of the insulin system, ensures sufficient serum glucose in times of fasting. In the race for new therapeutics for diabetes, one focus of study has been antagonizing the ghrelin system in order to improve glucose tolerance. We provide evidence fo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473679/ https://www.ncbi.nlm.nih.gov/pubmed/26090621 http://dx.doi.org/10.1038/srep11452 |
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author | Kunath, Nicolas van Groen, Thomas Allison, David B. Kumar, Ashish Dozier-Sharpe, Monique Kadish, Inga |
author_facet | Kunath, Nicolas van Groen, Thomas Allison, David B. Kumar, Ashish Dozier-Sharpe, Monique Kadish, Inga |
author_sort | Kunath, Nicolas |
collection | PubMed |
description | The orexigenic hormone ghrelin, a potential antagonist of the insulin system, ensures sufficient serum glucose in times of fasting. In the race for new therapeutics for diabetes, one focus of study has been antagonizing the ghrelin system in order to improve glucose tolerance. We provide evidence for a differential role of a ghrelin agonist on glucose homeostasis in an Alzheimer’s disease mouse model fed a high–glycemic index diet as a constant challenge for glucose homeostasis. The ghrelin agonist impaired glucose tolerance immediately after administration but not in the long term. At the same time, the ghrelin agonist improved spatial learning in the mice, raised their activity levels, and reduced their body weight and fat mass. Immunoassay results showed a beneficial impact of long-term treatment on insulin signaling pathways in hippocampal tissue. The present results suggest that ghrelin might improve cognition in Alzheimer’s disease via a central nervous system mechanism involving insulin signaling. |
format | Online Article Text |
id | pubmed-4473679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44736792015-07-13 Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model Kunath, Nicolas van Groen, Thomas Allison, David B. Kumar, Ashish Dozier-Sharpe, Monique Kadish, Inga Sci Rep Article The orexigenic hormone ghrelin, a potential antagonist of the insulin system, ensures sufficient serum glucose in times of fasting. In the race for new therapeutics for diabetes, one focus of study has been antagonizing the ghrelin system in order to improve glucose tolerance. We provide evidence for a differential role of a ghrelin agonist on glucose homeostasis in an Alzheimer’s disease mouse model fed a high–glycemic index diet as a constant challenge for glucose homeostasis. The ghrelin agonist impaired glucose tolerance immediately after administration but not in the long term. At the same time, the ghrelin agonist improved spatial learning in the mice, raised their activity levels, and reduced their body weight and fat mass. Immunoassay results showed a beneficial impact of long-term treatment on insulin signaling pathways in hippocampal tissue. The present results suggest that ghrelin might improve cognition in Alzheimer’s disease via a central nervous system mechanism involving insulin signaling. Nature Publishing Group 2015-06-19 /pmc/articles/PMC4473679/ /pubmed/26090621 http://dx.doi.org/10.1038/srep11452 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Kunath, Nicolas van Groen, Thomas Allison, David B. Kumar, Ashish Dozier-Sharpe, Monique Kadish, Inga Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model |
title | Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model |
title_full | Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model |
title_fullStr | Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model |
title_full_unstemmed | Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model |
title_short | Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model |
title_sort | ghrelin agonist does not foster insulin resistance but improves cognition in an alzheimer’s disease mouse model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473679/ https://www.ncbi.nlm.nih.gov/pubmed/26090621 http://dx.doi.org/10.1038/srep11452 |
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