Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells

Adult T-cell leukaemia/lymphoma (ATL) is an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukaemia virus (HTLV)-1. The identification of new molecular targets for ATL prevention and treatment is desired. SIRT1, a nicotinamide adenine dinucleotide(+) -depende...

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Detalles Bibliográficos
Autores principales: Kozako, Tomohiro, Suzuki, Takayoshi, Yoshimitsu, Makoto, Uchida, Yuichiro, Kuroki, Ayako, Aikawa, Akiyoshi, Honda, Shin-ichiro, Arima, Naomichi, Soeda, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473680/
https://www.ncbi.nlm.nih.gov/pubmed/26091232
http://dx.doi.org/10.1038/srep11345

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