Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease

Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to neurodegeneration generally, BGN connectivity...

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Autores principales: Rolinski, Michal, Griffanti, Ludovica, Szewczyk-Krolikowski, Konrad, Menke, Ricarda A.L., Wilcock, Gordon K., Filippini, Nicola, Zamboni, Giovanna, Hu, Michele T.M., Mackay, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473718/
https://www.ncbi.nlm.nih.gov/pubmed/26106536
http://dx.doi.org/10.1016/j.nicl.2015.04.003
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author Rolinski, Michal
Griffanti, Ludovica
Szewczyk-Krolikowski, Konrad
Menke, Ricarda A.L.
Wilcock, Gordon K.
Filippini, Nicola
Zamboni, Giovanna
Hu, Michele T.M.
Mackay, Clare E.
author_facet Rolinski, Michal
Griffanti, Ludovica
Szewczyk-Krolikowski, Konrad
Menke, Ricarda A.L.
Wilcock, Gordon K.
Filippini, Nicola
Zamboni, Giovanna
Hu, Michele T.M.
Mackay, Clare E.
author_sort Rolinski, Michal
collection PubMed
description Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to neurodegeneration generally, BGN connectivity was assessed in 32 patients with early PD, 19 healthy controls and 31 patients with Alzheimer's disease (AD). Voxel-wise comparisons demonstrated decreased connectivity within the basal ganglia of patients with PD, when compared to patients with AD and healthy controls. No significant changes within the BGN were seen in AD, when compared to healthy controls. Moreover, measures of functional connectivity extracted from regions within the basal ganglia were significantly lower in the PD group. Consistent with previous radiotracer studies, the greatest change when compared to the healthy control group was seen in the posterior putamen of PD subjects. When combined into a single component score, this method differentiated PD from AD and healthy control subjects, with a diagnostic accuracy of 81%. Rs-fMRI can be used to demonstrate the aberrant functional connectivity within the basal ganglia of patients with early PD. These changes are likely to be representative of patho-physiological basal ganglia dysfunction and are not associated with generalised neurodegeneration seen in AD. Further studies are necessary to ascertain whether this method is sensitive enough to detect basal ganglia dysfunction in prodromal PD, and its utility as a potential diagnostic biomarker for premotor and early motoric disease.
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spelling pubmed-44737182015-06-23 Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease Rolinski, Michal Griffanti, Ludovica Szewczyk-Krolikowski, Konrad Menke, Ricarda A.L. Wilcock, Gordon K. Filippini, Nicola Zamboni, Giovanna Hu, Michele T.M. Mackay, Clare E. Neuroimage Clin Regular Article Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to neurodegeneration generally, BGN connectivity was assessed in 32 patients with early PD, 19 healthy controls and 31 patients with Alzheimer's disease (AD). Voxel-wise comparisons demonstrated decreased connectivity within the basal ganglia of patients with PD, when compared to patients with AD and healthy controls. No significant changes within the BGN were seen in AD, when compared to healthy controls. Moreover, measures of functional connectivity extracted from regions within the basal ganglia were significantly lower in the PD group. Consistent with previous radiotracer studies, the greatest change when compared to the healthy control group was seen in the posterior putamen of PD subjects. When combined into a single component score, this method differentiated PD from AD and healthy control subjects, with a diagnostic accuracy of 81%. Rs-fMRI can be used to demonstrate the aberrant functional connectivity within the basal ganglia of patients with early PD. These changes are likely to be representative of patho-physiological basal ganglia dysfunction and are not associated with generalised neurodegeneration seen in AD. Further studies are necessary to ascertain whether this method is sensitive enough to detect basal ganglia dysfunction in prodromal PD, and its utility as a potential diagnostic biomarker for premotor and early motoric disease. Elsevier 2015-04-09 /pmc/articles/PMC4473718/ /pubmed/26106536 http://dx.doi.org/10.1016/j.nicl.2015.04.003 Text en © 2015 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Regular Article
Rolinski, Michal
Griffanti, Ludovica
Szewczyk-Krolikowski, Konrad
Menke, Ricarda A.L.
Wilcock, Gordon K.
Filippini, Nicola
Zamboni, Giovanna
Hu, Michele T.M.
Mackay, Clare E.
Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
title Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
title_full Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
title_fullStr Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
title_full_unstemmed Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
title_short Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
title_sort aberrant functional connectivity within the basal ganglia of patients with parkinson's disease
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473718/
https://www.ncbi.nlm.nih.gov/pubmed/26106536
http://dx.doi.org/10.1016/j.nicl.2015.04.003
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