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Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings
Among individuals diagnosed with schizophrenia, approximately 20%–33% are recognized as treatment-resistant schizophrenia (TRS) patients. These TRS patients suffer more severely from the disease but struggle to benefit from existing antipsychotic treatments. A few recent studies suggested that schiz...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473730/ https://www.ncbi.nlm.nih.gov/pubmed/26106532 http://dx.doi.org/10.1016/j.nicl.2015.03.017 |
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author | Wang, Jicai Cao, Hongbao Liao, Yanhui Liu, Weiqing Tan, Liwen Tang, Yanqing Chen, Jindong Xu, Xiufeng Li, Haijun Luo, Chunrong Liu, Chunyu Ries Merikangas, Kathleen Calhoun, Vince Tang, Jinsong Shugart, Yin Yao Chen, Xiaogang |
author_facet | Wang, Jicai Cao, Hongbao Liao, Yanhui Liu, Weiqing Tan, Liwen Tang, Yanqing Chen, Jindong Xu, Xiufeng Li, Haijun Luo, Chunrong Liu, Chunyu Ries Merikangas, Kathleen Calhoun, Vince Tang, Jinsong Shugart, Yin Yao Chen, Xiaogang |
author_sort | Wang, Jicai |
collection | PubMed |
description | Among individuals diagnosed with schizophrenia, approximately 20%–33% are recognized as treatment-resistant schizophrenia (TRS) patients. These TRS patients suffer more severely from the disease but struggle to benefit from existing antipsychotic treatments. A few recent studies suggested that schizophrenia may be caused by impaired synaptic plasticity that manifests as functional dysconnectivity in the brain, however, few of those studies focused on the functional connectivity changes in the brains of TRS groups. In this study, we compared the whole brain connectivity variations in TRS patients, their unaffected siblings, and healthy controls. Connectivity network features between and within the 116 automated anatomical labeling (AAL) brain regions were calculated and compared using maps created with three contrasts: patient vs. control, patient vs. sibling, and sibling vs. control. To evaluate the predictive power of the selected features, we performed a multivariate classification approach. We also evaluated the influence of six important clinical measures (e.g. age, education level) on the connectivity features. This study identified abnormal significant connectivity changes of three patterns in TRS patients and their unaffected siblings: 1) 69 patient-specific connectivity (PCN); 2) 102 shared connectivity (SCN); and 3) 457 unshared connectivity (UCN). While the first two patterns were widely reported by previous non-TRS specific studies, we were among the first to report widespread significant connectivity differences between TRS patient groups and their healthy sibling groups. Observations of this study may provide new insights for the understanding of the neurophysiological mechanisms of TRS. |
format | Online Article Text |
id | pubmed-4473730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-44737302015-06-23 Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings Wang, Jicai Cao, Hongbao Liao, Yanhui Liu, Weiqing Tan, Liwen Tang, Yanqing Chen, Jindong Xu, Xiufeng Li, Haijun Luo, Chunrong Liu, Chunyu Ries Merikangas, Kathleen Calhoun, Vince Tang, Jinsong Shugart, Yin Yao Chen, Xiaogang Neuroimage Clin Article Among individuals diagnosed with schizophrenia, approximately 20%–33% are recognized as treatment-resistant schizophrenia (TRS) patients. These TRS patients suffer more severely from the disease but struggle to benefit from existing antipsychotic treatments. A few recent studies suggested that schizophrenia may be caused by impaired synaptic plasticity that manifests as functional dysconnectivity in the brain, however, few of those studies focused on the functional connectivity changes in the brains of TRS groups. In this study, we compared the whole brain connectivity variations in TRS patients, their unaffected siblings, and healthy controls. Connectivity network features between and within the 116 automated anatomical labeling (AAL) brain regions were calculated and compared using maps created with three contrasts: patient vs. control, patient vs. sibling, and sibling vs. control. To evaluate the predictive power of the selected features, we performed a multivariate classification approach. We also evaluated the influence of six important clinical measures (e.g. age, education level) on the connectivity features. This study identified abnormal significant connectivity changes of three patterns in TRS patients and their unaffected siblings: 1) 69 patient-specific connectivity (PCN); 2) 102 shared connectivity (SCN); and 3) 457 unshared connectivity (UCN). While the first two patterns were widely reported by previous non-TRS specific studies, we were among the first to report widespread significant connectivity differences between TRS patient groups and their healthy sibling groups. Observations of this study may provide new insights for the understanding of the neurophysiological mechanisms of TRS. Elsevier 2015-03-24 /pmc/articles/PMC4473730/ /pubmed/26106532 http://dx.doi.org/10.1016/j.nicl.2015.03.017 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wang, Jicai Cao, Hongbao Liao, Yanhui Liu, Weiqing Tan, Liwen Tang, Yanqing Chen, Jindong Xu, Xiufeng Li, Haijun Luo, Chunrong Liu, Chunyu Ries Merikangas, Kathleen Calhoun, Vince Tang, Jinsong Shugart, Yin Yao Chen, Xiaogang Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
title | Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
title_full | Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
title_fullStr | Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
title_full_unstemmed | Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
title_short | Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
title_sort | three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473730/ https://www.ncbi.nlm.nih.gov/pubmed/26106532 http://dx.doi.org/10.1016/j.nicl.2015.03.017 |
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