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Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia

OBJECTIVES: Reflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in patients with bipolar disorder (BD). In addition, we examined wh...

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Autores principales: Zhang, Liwen, Opmeer, Esther M., Ruhé, Henricus G., Aleman, André, van der Meer, Lisette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473805/
https://www.ncbi.nlm.nih.gov/pubmed/26106544
http://dx.doi.org/10.1016/j.nicl.2015.04.010
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author Zhang, Liwen
Opmeer, Esther M.
Ruhé, Henricus G.
Aleman, André
van der Meer, Lisette
author_facet Zhang, Liwen
Opmeer, Esther M.
Ruhé, Henricus G.
Aleman, André
van der Meer, Lisette
author_sort Zhang, Liwen
collection PubMed
description OBJECTIVES: Reflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in patients with bipolar disorder (BD). In addition, we examined whether potential abnormal brain activation in BD patients could distinguish BD from patients with schizophrenia (SZ). METHODS: During functional magnetic resonance imaging (fMRI), 17 BD patients, 17 SZ patients and 21 healthy controls (HCs) performed a self-reflection task. The task consisted of sentences divided into three conditions: self-reflection, other-reflection and semantic control. RESULTS: BD patients showed less activation in the posterior cingulate cortex (PCC) extending to the precuneus during other-reflection compared to HCs (p = 0.028 FWE corrected on cluster-level within the regions of interest). In SZ patients, the level of activation in this area was in between BD patients and HCs, with no significant differences between patients with SZ and BD. There were no group differences in brain activation during self-reflection. Moreover, there was a positive correlation between the PCC/precuneus activation during other-reflection and cognitive insight in SZ patients, but not in BD patients. CONCLUSIONS: BD patients showed less activation in the PCC/precuneus during other-reflection. This may support an account of impaired integration of emotion and memory (evaluation of past and current other-related information) in BD patients. Correlation differences of the PCC/precuneus activation with the cognitive insight in patients with BD and SZ might reflect an important difference between these disorders, which may help to further explore potentially distinguishing markers.
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spelling pubmed-44738052015-06-23 Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia Zhang, Liwen Opmeer, Esther M. Ruhé, Henricus G. Aleman, André van der Meer, Lisette Neuroimage Clin Regular Article OBJECTIVES: Reflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in patients with bipolar disorder (BD). In addition, we examined whether potential abnormal brain activation in BD patients could distinguish BD from patients with schizophrenia (SZ). METHODS: During functional magnetic resonance imaging (fMRI), 17 BD patients, 17 SZ patients and 21 healthy controls (HCs) performed a self-reflection task. The task consisted of sentences divided into three conditions: self-reflection, other-reflection and semantic control. RESULTS: BD patients showed less activation in the posterior cingulate cortex (PCC) extending to the precuneus during other-reflection compared to HCs (p = 0.028 FWE corrected on cluster-level within the regions of interest). In SZ patients, the level of activation in this area was in between BD patients and HCs, with no significant differences between patients with SZ and BD. There were no group differences in brain activation during self-reflection. Moreover, there was a positive correlation between the PCC/precuneus activation during other-reflection and cognitive insight in SZ patients, but not in BD patients. CONCLUSIONS: BD patients showed less activation in the PCC/precuneus during other-reflection. This may support an account of impaired integration of emotion and memory (evaluation of past and current other-related information) in BD patients. Correlation differences of the PCC/precuneus activation with the cognitive insight in patients with BD and SZ might reflect an important difference between these disorders, which may help to further explore potentially distinguishing markers. Elsevier 2015-04-22 /pmc/articles/PMC4473805/ /pubmed/26106544 http://dx.doi.org/10.1016/j.nicl.2015.04.010 Text en © 2015 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Regular Article
Zhang, Liwen
Opmeer, Esther M.
Ruhé, Henricus G.
Aleman, André
van der Meer, Lisette
Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia
title Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia
title_full Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia
title_fullStr Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia
title_full_unstemmed Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia
title_short Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia
title_sort brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: comparison to schizophrenia
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473805/
https://www.ncbi.nlm.nih.gov/pubmed/26106544
http://dx.doi.org/10.1016/j.nicl.2015.04.010
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