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Incidence and extent of TDP-43 accumulation in aging human brain

INTRODUCTION: The transactivation response element DNA-binding protein 43 kDa (TDP-43) is a major component of the ubiquitin-positive and tau-negative inclusions in frontotemporal lobar degeneration and sporadic amyotrophic lateral sclerosis (ALS). TDP-43 may accumulate in cases of Alzheimer’s disea...

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Detalles Bibliográficos
Autores principales:	Uchino, Akiko, Takao, Masaki, Hatsuta, Hiroyuki, Sumikura, Hiroyuki, Nakano, Yuta, Nogami, Akane, Saito, Yuko, Arai, Tomio, Nishiyama, Kazutoshi, Murayama, Shigeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473839/ https://www.ncbi.nlm.nih.gov/pubmed/26091809 http://dx.doi.org/10.1186/s40478-015-0215-1

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