Implementation of Quantitative and Systems Pharmacology in Large Pharma

Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug developmen...

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Autores principales: Visser, S A G, de Alwis, D P, Kerbusch, T, Stone, J A, Allerheiligen, S R B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474169/
https://www.ncbi.nlm.nih.gov/pubmed/25338195
http://dx.doi.org/10.1038/psp.2014.40
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author Visser, S A G
de Alwis, D P
Kerbusch, T
Stone, J A
Allerheiligen, S R B
author_facet Visser, S A G
de Alwis, D P
Kerbusch, T
Stone, J A
Allerheiligen, S R B
author_sort Visser, S A G
collection PubMed
description Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment through significant cost avoidance. Critical factors for the successful implementation, examples on impact on decision making with associated return of investment, and drivers for continued success are discussed.
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spelling pubmed-44741692015-06-19 Implementation of Quantitative and Systems Pharmacology in Large Pharma Visser, S A G de Alwis, D P Kerbusch, T Stone, J A Allerheiligen, S R B CPT Pharmacometrics Syst Pharmacol Review Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment through significant cost avoidance. Critical factors for the successful implementation, examples on impact on decision making with associated return of investment, and drivers for continued success are discussed. Nature Publishing Group 2014-10 2014-10-22 /pmc/articles/PMC4474169/ /pubmed/25338195 http://dx.doi.org/10.1038/psp.2014.40 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Review
Visser, S A G
de Alwis, D P
Kerbusch, T
Stone, J A
Allerheiligen, S R B
Implementation of Quantitative and Systems Pharmacology in Large Pharma
title Implementation of Quantitative and Systems Pharmacology in Large Pharma
title_full Implementation of Quantitative and Systems Pharmacology in Large Pharma
title_fullStr Implementation of Quantitative and Systems Pharmacology in Large Pharma
title_full_unstemmed Implementation of Quantitative and Systems Pharmacology in Large Pharma
title_short Implementation of Quantitative and Systems Pharmacology in Large Pharma
title_sort implementation of quantitative and systems pharmacology in large pharma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474169/
https://www.ncbi.nlm.nih.gov/pubmed/25338195
http://dx.doi.org/10.1038/psp.2014.40
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