Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling

We modeled cellular epidermal growth factor receptor (EGFR) tyrosine phosphorylation dynamics in the presence of receptor-targeting kinase inhibitors (e.g., gefitinib) or antibodies (e.g., cetuximab) to identify systematically the factors that contribute most to the ability of the therapeutics to an...

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Detalles Bibliográficos
Autores principales: Monast, C S, Lazzara, M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474171/
https://www.ncbi.nlm.nih.gov/pubmed/25317724
http://dx.doi.org/10.1038/psp.2014.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474171/
https://www.ncbi.nlm.nih.gov/pubmed/25317724
http://dx.doi.org/10.1038/psp.2014.39

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