DNA copy number analysis of Grade II–III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status

INTRODUCTION: Isocitrate dehydrogenase (IDH) mutation status and grade define subgroups of diffuse gliomas differing based on age, tumor location, presentation, and prognosis. While some biologic differences between IDH mutated (IDH(mut)) and wild-type (IDH(wt)) gliomas are clear, the distinct alter...

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Detalles Bibliográficos
Autores principales: Cohen, Adam, Sato, Mariko, Aldape, Kenneth, Mason, Clinton C., Alfaro-Munoz, Kristin, Heathcock, Lindsey, South, Sarah T., Abegglen, Lisa M., Schiffman, Joshua D., Colman, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474351/
https://www.ncbi.nlm.nih.gov/pubmed/26091668
http://dx.doi.org/10.1186/s40478-015-0213-3

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