Patient-derived hepatitis C virus inhibits CD4(+) but not CD8(+) T lymphocyte proliferation in primary T cells

BACKGROUND: Hepatitis C virus (HCV) can replicate in cells of the immune system and productively propagate in primary T lymphocytes in vitro. We aimed to determine whether exposure to authentic, patient-derived HCV can modify the proliferation capacity, susceptibility to apoptosis and phenotype of T...

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Detalles Bibliográficos
Autores principales: MacParland, Sonya A., Chen, Annie Y., Corkum, Christopher P., Pham, Tram N.Q., Michalak, Tomasz I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474354/
https://www.ncbi.nlm.nih.gov/pubmed/26084511
http://dx.doi.org/10.1186/s12985-015-0322-4

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