Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014

The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case–control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, a...

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Autores principales: McAnerney, Johanna M, Treurnicht, Florette, Walaza, Sibongile, Cohen, Adam L, Tempia, Stefano, Mtshali, Senzo, Buys, Amelia, Blumberg, Lucille, Cohen, Cheryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474497/
https://www.ncbi.nlm.nih.gov/pubmed/25865249
http://dx.doi.org/10.1111/irv.12314
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author McAnerney, Johanna M
Treurnicht, Florette
Walaza, Sibongile
Cohen, Adam L
Tempia, Stefano
Mtshali, Senzo
Buys, Amelia
Blumberg, Lucille
Cohen, Cheryl
author_facet McAnerney, Johanna M
Treurnicht, Florette
Walaza, Sibongile
Cohen, Adam L
Tempia, Stefano
Mtshali, Senzo
Buys, Amelia
Blumberg, Lucille
Cohen, Cheryl
author_sort McAnerney, Johanna M
collection PubMed
description The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case–control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: −26·8–74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.
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spelling pubmed-44744972015-07-01 Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014 McAnerney, Johanna M Treurnicht, Florette Walaza, Sibongile Cohen, Adam L Tempia, Stefano Mtshali, Senzo Buys, Amelia Blumberg, Lucille Cohen, Cheryl Influenza Other Respir Viruses Short Article The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case–control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: −26·8–74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1. BlackWell Publishing Ltd 2015-07 2015-06-09 /pmc/articles/PMC4474497/ /pubmed/25865249 http://dx.doi.org/10.1111/irv.12314 Text en © 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Article
McAnerney, Johanna M
Treurnicht, Florette
Walaza, Sibongile
Cohen, Adam L
Tempia, Stefano
Mtshali, Senzo
Buys, Amelia
Blumberg, Lucille
Cohen, Cheryl
Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
title Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
title_full Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
title_fullStr Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
title_full_unstemmed Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
title_short Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
title_sort evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in south africa, 2014
topic Short Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474497/
https://www.ncbi.nlm.nih.gov/pubmed/25865249
http://dx.doi.org/10.1111/irv.12314
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