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Synthetic viability genomic screening defines Sae2 function in DNA repair

DNA double-strand break (DSB) repair by homologous recombination (HR) requires 3′ single-stranded DNA (ssDNA) generation by 5′ DNA-end resection. During meiosis, yeast Sae2 cooperates with the nuclease Mre11 to remove covalently bound Spo11 from DSB termini, allowing resection and HR to ensue. Mitot...

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Detalles Bibliográficos
Autores principales:	Puddu, Fabio, Oelschlaegel, Tobias, Guerini, Ilaria, Geisler, Nicola J, Niu, Hengyao, Herzog, Mareike, Salguero, Israel, Ochoa-Montaño, Bernardo, Viré, Emmanuelle, Sung, Patrick, Adams, David J, Keane, Thomas M, Jackson, Stephen P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474527/ https://www.ncbi.nlm.nih.gov/pubmed/25899817 http://dx.doi.org/10.15252/embj.201590973

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