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Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling

Stress caused by accumulation of misfolded proteins within the endoplasmic reticulum (ER) elicits a cellular unfolded protein response (UPR) aimed at maintaining protein-folding capacity. PERK, a key upstream component, recognizes ER stress via its luminal sensor/transducer domain, but the molecular...

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Detalles Bibliográficos
Autores principales:	Carrara, Marta, Prischi, Filippo, Nowak, Piotr R, Ali, Maruf MU
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474532/ https://www.ncbi.nlm.nih.gov/pubmed/25925385 http://dx.doi.org/10.15252/embj.201489183

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