An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1

BACKGROUND: Multi-walled carbon nanotubes (MWCNTs) represent a human health risk as mice exposed by inhalation display pulmonary fibrosis. Production of IL-1β via inflammasome activation is a mechanism of MWCNT-induced acute inflammation and has been implicated in chronic fibrogenesis. Mice sensitiz...

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Detalles Bibliográficos
Autores principales: Shipkowski, Kelly A., Taylor, Alexia J., Thompson, Elizabeth A., Glista-Baker, Ellen E., Sayers, Brian C., Messenger, Zachary J., Bauer, Rebecca N., Jaspers, Ilona, Bonner, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474696/
https://www.ncbi.nlm.nih.gov/pubmed/26091108
http://dx.doi.org/10.1371/journal.pone.0128888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474696/
https://www.ncbi.nlm.nih.gov/pubmed/26091108
http://dx.doi.org/10.1371/journal.pone.0128888

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