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Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma
BACKGROUND: Genitourinary embryonal rhabdomyosarcoma is rarely reported in China. This retrospective analysis aimed to characterize the clinicopathologic features and treatment outcomes of genitourinary embryonal rhabdomyosarcoma in a sample of Chinese patients. METHODS: Basic demographic and clinic...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475326/ https://www.ncbi.nlm.nih.gov/pubmed/26018798 http://dx.doi.org/10.1186/s12957-015-0574-x |
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author | Zhan, Xiao-kai Zhang, Sen Cao, Bang-wei Wang, Jin-wan Li, Jun-ling Sun, Yong-kun Zhang, Wen Yang, Lin Zhou, Ai-ping bali Chi, Yi-he Li, Ye-xiong Ma, Jian-hui Li, Chang-ling |
author_facet | Zhan, Xiao-kai Zhang, Sen Cao, Bang-wei Wang, Jin-wan Li, Jun-ling Sun, Yong-kun Zhang, Wen Yang, Lin Zhou, Ai-ping bali Chi, Yi-he Li, Ye-xiong Ma, Jian-hui Li, Chang-ling |
author_sort | Zhan, Xiao-kai |
collection | PubMed |
description | BACKGROUND: Genitourinary embryonal rhabdomyosarcoma is rarely reported in China. This retrospective analysis aimed to characterize the clinicopathologic features and treatment outcomes of genitourinary embryonal rhabdomyosarcoma in a sample of Chinese patients. METHODS: Basic demographic and clinical data of 29 patients, who were diagnosed with genitourinary embryonal rhabdomyosarcoma between January 2000 and December 2011, were retrieved and analyzed. RESULTS: In these patients, 25 were males and 4 were females with a median age of 12 years. Paratesticule was the most common lesion site, followed by the prostate, bladder, and vagina. The median tumor size was 5.80 cm. Six patients had clinically positive regional nodes. At the initial diagnosis, patients had a metastatic disease. According to the TNM staging classification for the IRS-IV, phase I lesions were detected in ten cases, phase II lesions in six cases, phase III lesions in four cases, and phase IV lesions in nine cases. The median survival of all patients was 63 (range from 6 to 118) months. The 1-, 3-, and 5-year survival rates for these patients were 93%, 83%, and 52%, respectively. Multivariate analyses demonstrated that staging and anemia were significant predictors of prognosis. CONCLUSIONS: Our findings suggest that metastasis predicts a poor prognosis. Chemotherapy played an important role in comprehensive treatment. Palliative and neo-adjuvant chemotherapy could increase median survival time. |
format | Online Article Text |
id | pubmed-4475326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44753262015-06-21 Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma Zhan, Xiao-kai Zhang, Sen Cao, Bang-wei Wang, Jin-wan Li, Jun-ling Sun, Yong-kun Zhang, Wen Yang, Lin Zhou, Ai-ping bali Chi, Yi-he Li, Ye-xiong Ma, Jian-hui Li, Chang-ling World J Surg Oncol Research BACKGROUND: Genitourinary embryonal rhabdomyosarcoma is rarely reported in China. This retrospective analysis aimed to characterize the clinicopathologic features and treatment outcomes of genitourinary embryonal rhabdomyosarcoma in a sample of Chinese patients. METHODS: Basic demographic and clinical data of 29 patients, who were diagnosed with genitourinary embryonal rhabdomyosarcoma between January 2000 and December 2011, were retrieved and analyzed. RESULTS: In these patients, 25 were males and 4 were females with a median age of 12 years. Paratesticule was the most common lesion site, followed by the prostate, bladder, and vagina. The median tumor size was 5.80 cm. Six patients had clinically positive regional nodes. At the initial diagnosis, patients had a metastatic disease. According to the TNM staging classification for the IRS-IV, phase I lesions were detected in ten cases, phase II lesions in six cases, phase III lesions in four cases, and phase IV lesions in nine cases. The median survival of all patients was 63 (range from 6 to 118) months. The 1-, 3-, and 5-year survival rates for these patients were 93%, 83%, and 52%, respectively. Multivariate analyses demonstrated that staging and anemia were significant predictors of prognosis. CONCLUSIONS: Our findings suggest that metastasis predicts a poor prognosis. Chemotherapy played an important role in comprehensive treatment. Palliative and neo-adjuvant chemotherapy could increase median survival time. BioMed Central 2015-05-28 /pmc/articles/PMC4475326/ /pubmed/26018798 http://dx.doi.org/10.1186/s12957-015-0574-x Text en © Zhan et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Zhan, Xiao-kai Zhang, Sen Cao, Bang-wei Wang, Jin-wan Li, Jun-ling Sun, Yong-kun Zhang, Wen Yang, Lin Zhou, Ai-ping bali Chi, Yi-he Li, Ye-xiong Ma, Jian-hui Li, Chang-ling Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma |
title | Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma |
title_full | Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma |
title_fullStr | Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma |
title_full_unstemmed | Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma |
title_short | Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma |
title_sort | clinicopathological characteristics and treatment outcomes of chinese patients with genitourinary embryonal rhabdomyosarcoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475326/ https://www.ncbi.nlm.nih.gov/pubmed/26018798 http://dx.doi.org/10.1186/s12957-015-0574-x |
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