Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer

Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or...

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Detalles Bibliográficos
Autores principales: Kampan, Nirmala Chandralega, Madondo, Mutsa Tatenda, McNally, Orla M., Quinn, Michael, Plebanski, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475536/
https://www.ncbi.nlm.nih.gov/pubmed/26137480
http://dx.doi.org/10.1155/2015/413076
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author Kampan, Nirmala Chandralega
Madondo, Mutsa Tatenda
McNally, Orla M.
Quinn, Michael
Plebanski, Magdalena
author_facet Kampan, Nirmala Chandralega
Madondo, Mutsa Tatenda
McNally, Orla M.
Quinn, Michael
Plebanski, Magdalena
author_sort Kampan, Nirmala Chandralega
collection PubMed
description Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.
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spelling pubmed-44755362015-07-01 Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer Kampan, Nirmala Chandralega Madondo, Mutsa Tatenda McNally, Orla M. Quinn, Michael Plebanski, Magdalena Biomed Res Int Review Article Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound. Hindawi Publishing Corporation 2015 2015-06-07 /pmc/articles/PMC4475536/ /pubmed/26137480 http://dx.doi.org/10.1155/2015/413076 Text en Copyright © 2015 Nirmala Chandralega Kampan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kampan, Nirmala Chandralega
Madondo, Mutsa Tatenda
McNally, Orla M.
Quinn, Michael
Plebanski, Magdalena
Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
title Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
title_full Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
title_fullStr Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
title_full_unstemmed Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
title_short Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
title_sort paclitaxel and its evolving role in the management of ovarian cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475536/
https://www.ncbi.nlm.nih.gov/pubmed/26137480
http://dx.doi.org/10.1155/2015/413076
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