Lithium and Valproate Levels Do Not Correlate with Ketamine's Antidepressant Efficacy in Treatment-Resistant Bipolar Depression

Ketamine and lithium both inhibit glycogen synthase kinase 3. In addition, lithium and ketamine have synergistic antidepressant-like effects at individually subeffective doses in rodents. We hypothesized that ketamine's antidepressant effects would be improved by therapeutic doses of lithium ve...

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Detalles Bibliográficos
Autores principales: Xu, Annie J., Niciu, Mark J., Lundin, Nancy B., Luckenbaugh, David A., Ionescu, Dawn F., Richards, Erica M., Vande Voort, Jennifer L., Ballard, Elizabeth D., Brutsche, Nancy E., Machado-Vieira, Rodrigo, Zarate, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475570/
https://www.ncbi.nlm.nih.gov/pubmed/26137324
http://dx.doi.org/10.1155/2015/858251

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