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Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia

BACKGROUND: Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. MATERIALS AND METHODS: Sixty-six patients with maj...

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Autores principales: Eghbali, A, Taherahmadi, H, Bagheri, B, Nikanjam, S, Ebrahimi, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Sadoughi University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475628/
https://www.ncbi.nlm.nih.gov/pubmed/26131346
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author Eghbali, A
Taherahmadi, H
Bagheri, B
Nikanjam, S
Ebrahimi, L
author_facet Eghbali, A
Taherahmadi, H
Bagheri, B
Nikanjam, S
Ebrahimi, L
author_sort Eghbali, A
collection PubMed
description BACKGROUND: Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. MATERIALS AND METHODS: Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels were measured during 3 months in patients with no symptoms of infection. It was measured by enzyme-linked immunosorbent assay (ELISA). Ejection Fraction (EF), Fractional Shortening (FS) and Early/Late ratio (E/A) were studied by echocardiography. RESULTS: Fifty two percent were female and 48% were male. Mean age was 16 ± 9 years and the age range was3-26years. Mean serum ferritin level was1912 ± 1748 ng/dl and its range was from 303 to 8333 ng/dl. There were significant correlations between serum ferritin level and EF(r=0.3 and P=0.05) and also between serum ferritin level and FS. CONCLUSION: Due to significant association between serum ferritin level and echo parameters, it is beneficial that all patients with major thalassemia undergo echocardiography to gain better understating about cardiac function.
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spelling pubmed-44756282015-06-30 Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia Eghbali, A Taherahmadi, H Bagheri, B Nikanjam, S Ebrahimi, L Iran J Ped Hematol Oncol Original Article BACKGROUND: Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. MATERIALS AND METHODS: Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels were measured during 3 months in patients with no symptoms of infection. It was measured by enzyme-linked immunosorbent assay (ELISA). Ejection Fraction (EF), Fractional Shortening (FS) and Early/Late ratio (E/A) were studied by echocardiography. RESULTS: Fifty two percent were female and 48% were male. Mean age was 16 ± 9 years and the age range was3-26years. Mean serum ferritin level was1912 ± 1748 ng/dl and its range was from 303 to 8333 ng/dl. There were significant correlations between serum ferritin level and EF(r=0.3 and P=0.05) and also between serum ferritin level and FS. CONCLUSION: Due to significant association between serum ferritin level and echo parameters, it is beneficial that all patients with major thalassemia undergo echocardiography to gain better understating about cardiac function. Shahid Sadoughi University of Medical Sciences 2015 2015-04-20 /pmc/articles/PMC4475628/ /pubmed/26131346 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Eghbali, A
Taherahmadi, H
Bagheri, B
Nikanjam, S
Ebrahimi, L
Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
title Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
title_full Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
title_fullStr Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
title_full_unstemmed Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
title_short Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
title_sort association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475628/
https://www.ncbi.nlm.nih.gov/pubmed/26131346
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