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Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report
Accidental overdose of chemotherapy drugs including vinblastin (VBL) have been reported in the literature. As VBL overdose is potentially fatal, we decided to introduce a 2-year-old girl affected by langerhans’ cell histiocytosis who was accidentally injected 10-times the prescribed dose of VBL (16...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shahid Sadoughi University of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475633/ https://www.ncbi.nlm.nih.gov/pubmed/26131351 |
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author | Bordbar, M.R Bazrafshan, A Karimi, M |
author_facet | Bordbar, M.R Bazrafshan, A Karimi, M |
author_sort | Bordbar, M.R |
collection | PubMed |
description | Accidental overdose of chemotherapy drugs including vinblastin (VBL) have been reported in the literature. As VBL overdose is potentially fatal, we decided to introduce a 2-year-old girl affected by langerhans’ cell histiocytosis who was accidentally injected 10-times the prescribed dose of VBL (16 mg), and was saved with whole blood double exchange transfusion at 8 and 20 hrs after the accidental injection. The earliest manifestations were irritability and sinus tachycardia which alleviated after starting digoxin and at the end of the 2(nd) exchange transfusion. Other reported adverse effects were myelosuppression, weakness of extremities, diminished deep tendon reflexes and ileus which resolved at the time of discharge from hospital on day 13 of admission. It is speculated that exchange transfusion is an effective modality in reducing the serious adverse effects of VBL overdose. |
format | Online Article Text |
id | pubmed-4475633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Shahid Sadoughi University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44756332015-06-30 Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report Bordbar, M.R Bazrafshan, A Karimi, M Iran J Ped Hematol Oncol Original Article Accidental overdose of chemotherapy drugs including vinblastin (VBL) have been reported in the literature. As VBL overdose is potentially fatal, we decided to introduce a 2-year-old girl affected by langerhans’ cell histiocytosis who was accidentally injected 10-times the prescribed dose of VBL (16 mg), and was saved with whole blood double exchange transfusion at 8 and 20 hrs after the accidental injection. The earliest manifestations were irritability and sinus tachycardia which alleviated after starting digoxin and at the end of the 2(nd) exchange transfusion. Other reported adverse effects were myelosuppression, weakness of extremities, diminished deep tendon reflexes and ileus which resolved at the time of discharge from hospital on day 13 of admission. It is speculated that exchange transfusion is an effective modality in reducing the serious adverse effects of VBL overdose. Shahid Sadoughi University of Medical Sciences 2015 2015-04-20 /pmc/articles/PMC4475633/ /pubmed/26131351 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bordbar, M.R Bazrafshan, A Karimi, M Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report |
title | Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report |
title_full | Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report |
title_fullStr | Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report |
title_full_unstemmed | Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report |
title_short | Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report |
title_sort | successful management of vinblastin overdose with exchange transfusion: a case report |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475633/ https://www.ncbi.nlm.nih.gov/pubmed/26131351 |
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