The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease

OBJECTIVE(S): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer’s disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS: BMSCs were obtained from the bo...

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Autores principales: Eftekharzadeh, Mina, Nobakht, Maliheh, Alizadeh, Akram, Soleimani, Mansooreh, Hajghasem, Mahmood, Kordestani Shargh, Bahareh, Karkuki Osguei, Nushin, Behnam, Babak, Samadikuchaksaraei, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475662/
https://www.ncbi.nlm.nih.gov/pubmed/26124940
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author Eftekharzadeh, Mina
Nobakht, Maliheh
Alizadeh, Akram
Soleimani, Mansooreh
Hajghasem, Mahmood
Kordestani Shargh, Bahareh
Karkuki Osguei, Nushin
Behnam, Babak
Samadikuchaksaraei, Ali
author_facet Eftekharzadeh, Mina
Nobakht, Maliheh
Alizadeh, Akram
Soleimani, Mansooreh
Hajghasem, Mahmood
Kordestani Shargh, Bahareh
Karkuki Osguei, Nushin
Behnam, Babak
Samadikuchaksaraei, Ali
author_sort Eftekharzadeh, Mina
collection PubMed
description OBJECTIVE(S): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer’s disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. RESULTS: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. CONCLUSION: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer’s disease in rat model.
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spelling pubmed-44756622015-06-29 The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease Eftekharzadeh, Mina Nobakht, Maliheh Alizadeh, Akram Soleimani, Mansooreh Hajghasem, Mahmood Kordestani Shargh, Bahareh Karkuki Osguei, Nushin Behnam, Babak Samadikuchaksaraei, Ali Iran J Basic Med Sci Short Communication OBJECTIVE(S): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer’s disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. RESULTS: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. CONCLUSION: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer’s disease in rat model. Mashhad University of Medical Sciences 2015-05 /pmc/articles/PMC4475662/ /pubmed/26124940 Text en Copyright: © Iranian Journal of Basic Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Eftekharzadeh, Mina
Nobakht, Maliheh
Alizadeh, Akram
Soleimani, Mansooreh
Hajghasem, Mahmood
Kordestani Shargh, Bahareh
Karkuki Osguei, Nushin
Behnam, Babak
Samadikuchaksaraei, Ali
The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
title The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
title_full The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
title_fullStr The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
title_full_unstemmed The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
title_short The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
title_sort effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of alzheimer’s disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475662/
https://www.ncbi.nlm.nih.gov/pubmed/26124940
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