Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients

We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D(3) in serum samples. Interestingly, individuals with a type 2 reaction associated with n...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandal, D., Reja, A.H.H., Biswas, N., Bhattacharyya, P., Patra, P.K., Bhattacharya, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475695/
https://www.ncbi.nlm.nih.gov/pubmed/26106480
http://dx.doi.org/10.1016/j.nmni.2015.04.001
Descripción
Sumario:We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D(3) in serum samples. Interestingly, individuals with a type 2 reaction associated with neuritis/erythema nodosum leprosum had very low VDR mRNA expression levels, ranging from 5% to 10%, compared to that of healthy control subjects; these patients also had a high bacilli index, ranging from 3+ to 5+. This is the first report to indicate that VDR expression levels may determine the complexity and severity of the progression of leprosy.

Ejemplares similares