Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients

We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D(3) in serum samples. Interestingly, individuals with a type 2 reaction associated with n...

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Detalles Bibliográficos
Autores principales: Mandal, D., Reja, A.H.H., Biswas, N., Bhattacharyya, P., Patra, P.K., Bhattacharya, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475695/
https://www.ncbi.nlm.nih.gov/pubmed/26106480
http://dx.doi.org/10.1016/j.nmni.2015.04.001
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author Mandal, D.
Reja, A.H.H.
Biswas, N.
Bhattacharyya, P.
Patra, P.K.
Bhattacharya, B.
author_facet Mandal, D.
Reja, A.H.H.
Biswas, N.
Bhattacharyya, P.
Patra, P.K.
Bhattacharya, B.
author_sort Mandal, D.
collection PubMed
description We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D(3) in serum samples. Interestingly, individuals with a type 2 reaction associated with neuritis/erythema nodosum leprosum had very low VDR mRNA expression levels, ranging from 5% to 10%, compared to that of healthy control subjects; these patients also had a high bacilli index, ranging from 3+ to 5+. This is the first report to indicate that VDR expression levels may determine the complexity and severity of the progression of leprosy.
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spelling pubmed-44756952015-06-23 Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients Mandal, D. Reja, A.H.H. Biswas, N. Bhattacharyya, P. Patra, P.K. Bhattacharya, B. New Microbes New Infect Original Article We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D(3) in serum samples. Interestingly, individuals with a type 2 reaction associated with neuritis/erythema nodosum leprosum had very low VDR mRNA expression levels, ranging from 5% to 10%, compared to that of healthy control subjects; these patients also had a high bacilli index, ranging from 3+ to 5+. This is the first report to indicate that VDR expression levels may determine the complexity and severity of the progression of leprosy. Elsevier 2015-04-16 /pmc/articles/PMC4475695/ /pubmed/26106480 http://dx.doi.org/10.1016/j.nmni.2015.04.001 Text en © 2015 New Microbes and New Infections published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Mandal, D.
Reja, A.H.H.
Biswas, N.
Bhattacharyya, P.
Patra, P.K.
Bhattacharya, B.
Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
title Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
title_full Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
title_fullStr Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
title_full_unstemmed Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
title_short Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
title_sort vitamin d receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475695/
https://www.ncbi.nlm.nih.gov/pubmed/26106480
http://dx.doi.org/10.1016/j.nmni.2015.04.001
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