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A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model

Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory effect (SME). Hypotheses: a novel NiTi-SMA plate stabilizes tibia osteotomies in...

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Autores principales: Müller, Christian W., Pfeifer, Ronny, Meier, Karen, Decker, Sebastian, Reifenrath, Janin, Gösling, Thomas, Wesling, Volker, Krettek, Christian, Hurschler, Christof, Krämer, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475735/
https://www.ncbi.nlm.nih.gov/pubmed/26167493
http://dx.doi.org/10.1155/2015/652940
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author Müller, Christian W.
Pfeifer, Ronny
Meier, Karen
Decker, Sebastian
Reifenrath, Janin
Gösling, Thomas
Wesling, Volker
Krettek, Christian
Hurschler, Christof
Krämer, Manuel
author_facet Müller, Christian W.
Pfeifer, Ronny
Meier, Karen
Decker, Sebastian
Reifenrath, Janin
Gösling, Thomas
Wesling, Volker
Krettek, Christian
Hurschler, Christof
Krämer, Manuel
author_sort Müller, Christian W.
collection PubMed
description Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory effect (SME). Hypotheses: a novel NiTi-SMA plate stabilizes tibia osteotomies in rabbits. After noninvasive electromagnetic induction heating the alloy exhibits the SME and the plate changes towards higher stiffness (inverse dynamization) resulting in increased fixation stiffness and equal or better bony healing. In 14 rabbits, 1.0 mm tibia osteotomies were fixed with our experimental plate. Animals were randomised for control or induction heating at three weeks postoperatively. Repetitive X-ray imaging and in vivo measurements of bending stiffness were performed. After sacrifice at 8 weeks, macroscopic evaluation, µCT, and post mortem bending tests of the tibiae were carried out. One death and one early implant dislocation occurred. Following electromagnetic induction heating, radiographic and macroscopic changes of the implant proved successful SME activation. All osteotomies healed. In the treatment group, bending stiffness increased over time. Differences between groups were not significant. In conclusion, we demonstrated successful healing of rabbit tibia osteotomies using our novel NiTi-SMA plate. We demonstrated shape-changing SME in-vivo through transcutaneous electromagnetic induction heating. Thus, future orthopaedic implants could be modified without additional surgery.
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spelling pubmed-44757352015-07-12 A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model Müller, Christian W. Pfeifer, Ronny Meier, Karen Decker, Sebastian Reifenrath, Janin Gösling, Thomas Wesling, Volker Krettek, Christian Hurschler, Christof Krämer, Manuel Biomed Res Int Research Article Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory effect (SME). Hypotheses: a novel NiTi-SMA plate stabilizes tibia osteotomies in rabbits. After noninvasive electromagnetic induction heating the alloy exhibits the SME and the plate changes towards higher stiffness (inverse dynamization) resulting in increased fixation stiffness and equal or better bony healing. In 14 rabbits, 1.0 mm tibia osteotomies were fixed with our experimental plate. Animals were randomised for control or induction heating at three weeks postoperatively. Repetitive X-ray imaging and in vivo measurements of bending stiffness were performed. After sacrifice at 8 weeks, macroscopic evaluation, µCT, and post mortem bending tests of the tibiae were carried out. One death and one early implant dislocation occurred. Following electromagnetic induction heating, radiographic and macroscopic changes of the implant proved successful SME activation. All osteotomies healed. In the treatment group, bending stiffness increased over time. Differences between groups were not significant. In conclusion, we demonstrated successful healing of rabbit tibia osteotomies using our novel NiTi-SMA plate. We demonstrated shape-changing SME in-vivo through transcutaneous electromagnetic induction heating. Thus, future orthopaedic implants could be modified without additional surgery. Hindawi Publishing Corporation 2015 2015-06-08 /pmc/articles/PMC4475735/ /pubmed/26167493 http://dx.doi.org/10.1155/2015/652940 Text en Copyright © 2015 Christian W. Müller et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Müller, Christian W.
Pfeifer, Ronny
Meier, Karen
Decker, Sebastian
Reifenrath, Janin
Gösling, Thomas
Wesling, Volker
Krettek, Christian
Hurschler, Christof
Krämer, Manuel
A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model
title A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model
title_full A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model
title_fullStr A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model
title_full_unstemmed A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model
title_short A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Model
title_sort novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475735/
https://www.ncbi.nlm.nih.gov/pubmed/26167493
http://dx.doi.org/10.1155/2015/652940
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