Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers

The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this in...

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Detalles Bibliográficos
Autores principales: Clarke, Robert, Cook, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475795/
https://www.ncbi.nlm.nih.gov/pubmed/26157705
http://dx.doi.org/10.3389/fonc.2015.00140
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author Clarke, Robert
Cook, Katherine L.
author_facet Clarke, Robert
Cook, Katherine L.
author_sort Clarke, Robert
collection PubMed
description The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.
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spelling pubmed-44757952015-07-08 Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers Clarke, Robert Cook, Katherine L. Front Oncol Oncology The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival. Frontiers Media S.A. 2015-06-22 /pmc/articles/PMC4475795/ /pubmed/26157705 http://dx.doi.org/10.3389/fonc.2015.00140 Text en Copyright © 2015 Clarke and Cook. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Clarke, Robert
Cook, Katherine L.
Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers
title Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers
title_full Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers
title_fullStr Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers
title_full_unstemmed Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers
title_short Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers
title_sort unfolding the role of stress response signaling in endocrine resistant breast cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475795/
https://www.ncbi.nlm.nih.gov/pubmed/26157705
http://dx.doi.org/10.3389/fonc.2015.00140
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