Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard...

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Autores principales: Lozynskyi, Andrii, Zimenkovsky, Borys, Lesyk, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientia Pharmaceutica 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475803/
https://www.ncbi.nlm.nih.gov/pubmed/26171321
http://dx.doi.org/10.3797/scipharm.1408-05
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author Lozynskyi, Andrii
Zimenkovsky, Borys
Lesyk, Roman
author_facet Lozynskyi, Andrii
Zimenkovsky, Borys
Lesyk, Roman
author_sort Lozynskyi, Andrii
collection PubMed
description Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard National Cancer Institute 60 cancer cell line assay. Promising compounds 3e, 3g, and 3h with moderate antitumor activity were identified among the synthesized series.
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spelling pubmed-44758032015-07-13 Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides Lozynskyi, Andrii Zimenkovsky, Borys Lesyk, Roman Sci Pharm Research Article Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard National Cancer Institute 60 cancer cell line assay. Promising compounds 3e, 3g, and 3h with moderate antitumor activity were identified among the synthesized series. Scientia Pharmaceutica 2014-09-15 2014 /pmc/articles/PMC4475803/ /pubmed/26171321 http://dx.doi.org/10.3797/scipharm.1408-05 Text en © Lozynskyi et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lozynskyi, Andrii
Zimenkovsky, Borys
Lesyk, Roman
Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
title Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
title_full Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
title_fullStr Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
title_full_unstemmed Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
title_short Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
title_sort synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on cinnamic acid amides
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475803/
https://www.ncbi.nlm.nih.gov/pubmed/26171321
http://dx.doi.org/10.3797/scipharm.1408-05
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AT lesykroman synthesisandanticanceractivityofnewthiopyrano23dthiazolesbasedoncinnamicacidamides

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