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Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization

PURPOSE: Amphotericin B (AmB) is an effective anti-fungal and anti-leishmanial agent. However, AmB has low oral bioavailability (0.3%) and adverse effects (e.g., nephrotoxicity). The objectives of this study were to improve the oral bioavailability by entrapping AmB in pegylated (PEG) poly lactide c...

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Detalles Bibliográficos
Autores principales:	AL-Quadeib, Bushra T., Radwan, Mahasen A., Siller, Lidija, Horrocks, Benjamin, Wright, Matthew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475820/ https://www.ncbi.nlm.nih.gov/pubmed/26106277 http://dx.doi.org/10.1016/j.jsps.2014.11.004

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