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Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners

Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods: Eight...

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Autores principales: Armanfar, Mostafa, Jafari, Afshar, Dehghan, Gholam Reza, Abdizadeh, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476212/
https://www.ncbi.nlm.nih.gov/pubmed/26157720
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author Armanfar, Mostafa
Jafari, Afshar
Dehghan, Gholam Reza
Abdizadeh, Leila
author_facet Armanfar, Mostafa
Jafari, Afshar
Dehghan, Gholam Reza
Abdizadeh, Leila
author_sort Armanfar, Mostafa
collection PubMed
description Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods: Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n= 9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test. Results: The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin- 6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase. Conclusion: Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences.
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spelling pubmed-44762122015-07-08 Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners Armanfar, Mostafa Jafari, Afshar Dehghan, Gholam Reza Abdizadeh, Leila Med J Islam Repub Iran Original Article Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods: Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n= 9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test. Results: The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin- 6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase. Conclusion: Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences. Iran University of Medical Sciences 2015-04-20 /pmc/articles/PMC4476212/ /pubmed/26157720 Text en © 2015 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Armanfar, Mostafa
Jafari, Afshar
Dehghan, Gholam Reza
Abdizadeh, Leila
Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
title Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
title_full Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
title_fullStr Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
title_full_unstemmed Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
title_short Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
title_sort effect of coenzyme q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476212/
https://www.ncbi.nlm.nih.gov/pubmed/26157720
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