Cargando…
Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods: Eight...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iran University of Medical Sciences
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476212/ https://www.ncbi.nlm.nih.gov/pubmed/26157720 |
_version_ | 1782377572424744960 |
---|---|
author | Armanfar, Mostafa Jafari, Afshar Dehghan, Gholam Reza Abdizadeh, Leila |
author_facet | Armanfar, Mostafa Jafari, Afshar Dehghan, Gholam Reza Abdizadeh, Leila |
author_sort | Armanfar, Mostafa |
collection | PubMed |
description | Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods: Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n= 9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test. Results: The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin- 6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase. Conclusion: Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences. |
format | Online Article Text |
id | pubmed-4476212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Iran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44762122015-07-08 Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners Armanfar, Mostafa Jafari, Afshar Dehghan, Gholam Reza Abdizadeh, Leila Med J Islam Repub Iran Original Article Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods: Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n= 9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test. Results: The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin- 6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase. Conclusion: Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences. Iran University of Medical Sciences 2015-04-20 /pmc/articles/PMC4476212/ /pubmed/26157720 Text en © 2015 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Armanfar, Mostafa Jafari, Afshar Dehghan, Gholam Reza Abdizadeh, Leila Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
title | Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
title_full | Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
title_fullStr | Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
title_full_unstemmed | Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
title_short | Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
title_sort | effect of coenzyme q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476212/ https://www.ncbi.nlm.nih.gov/pubmed/26157720 |
work_keys_str_mv | AT armanfarmostafa effectofcoenzymeq10supplementationonexerciseinducedresponseofinflammatoryindicatorsandbloodlactateinmalerunners AT jafariafshar effectofcoenzymeq10supplementationonexerciseinducedresponseofinflammatoryindicatorsandbloodlactateinmalerunners AT dehghangholamreza effectofcoenzymeq10supplementationonexerciseinducedresponseofinflammatoryindicatorsandbloodlactateinmalerunners AT abdizadehleila effectofcoenzymeq10supplementationonexerciseinducedresponseofinflammatoryindicatorsandbloodlactateinmalerunners |