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Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin
Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iran University of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476218/ https://www.ncbi.nlm.nih.gov/pubmed/26157710 |
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author | Pordal, Amir-Hamzeh Hajmiresmail, Seyed Javad Assadpoor-Piranfar, Mohammad Hedayati, Mehdi Ajami, Marjan |
author_facet | Pordal, Amir-Hamzeh Hajmiresmail, Seyed Javad Assadpoor-Piranfar, Mohammad Hedayati, Mehdi Ajami, Marjan |
author_sort | Pordal, Amir-Hamzeh |
collection | PubMed |
description | Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins onoxysterol. Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during 2011-2012 withcoronary artery stenosis more than 75%, as determined by angiography, participated in the currentstudy. Their demographic information and history of smoking and taking atorvastatin was carefullyrecorded. Two milliliters of venous blood was obtained from each patient. The serum oxysterol levelof samples was measured using the enzyme-linked immunosorbent assay (ELISA) method. Statisticalanalysis was performed using SPSS v.19. Results: Eighty five patients completed the study. Mean age of patients was 64.4 years; 51 (60%)were male; 55 (68%) had acute coronary syndrome and 30 (32%) had chronic stable angina.Mean±SD of plasma level of oxysterol was 24.8±0.2 pmol/ml. The normal range of oxysterol levelwas 13pmol/ml. Mean±SD of plasma oxysterol level in patients under statin therapy was 24.4±2.1pmol/ml. In patients without receiving statins, plasma oxysterol level was 26.38±1.6pmol/ml. Conclusion: Findings of the present study indicated significant correlation between serum oxysteroland severity of coronary artery stenosis. It also demonstrated that receiving atorvastatin is associatedwith significant reduction of plasma oxysterol level. |
format | Online Article Text |
id | pubmed-4476218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Iran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44762182015-07-08 Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin Pordal, Amir-Hamzeh Hajmiresmail, Seyed Javad Assadpoor-Piranfar, Mohammad Hedayati, Mehdi Ajami, Marjan Med J Islam Repub Iran Original Article Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins onoxysterol. Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during 2011-2012 withcoronary artery stenosis more than 75%, as determined by angiography, participated in the currentstudy. Their demographic information and history of smoking and taking atorvastatin was carefullyrecorded. Two milliliters of venous blood was obtained from each patient. The serum oxysterol levelof samples was measured using the enzyme-linked immunosorbent assay (ELISA) method. Statisticalanalysis was performed using SPSS v.19. Results: Eighty five patients completed the study. Mean age of patients was 64.4 years; 51 (60%)were male; 55 (68%) had acute coronary syndrome and 30 (32%) had chronic stable angina.Mean±SD of plasma level of oxysterol was 24.8±0.2 pmol/ml. The normal range of oxysterol levelwas 13pmol/ml. Mean±SD of plasma oxysterol level in patients under statin therapy was 24.4±2.1pmol/ml. In patients without receiving statins, plasma oxysterol level was 26.38±1.6pmol/ml. Conclusion: Findings of the present study indicated significant correlation between serum oxysteroland severity of coronary artery stenosis. It also demonstrated that receiving atorvastatin is associatedwith significant reduction of plasma oxysterol level. Iran University of Medical Sciences 2015-03-14 /pmc/articles/PMC4476218/ /pubmed/26157710 Text en © 2015 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Pordal, Amir-Hamzeh Hajmiresmail, Seyed Javad Assadpoor-Piranfar, Mohammad Hedayati, Mehdi Ajami, Marjan Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
title | Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
title_full | Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
title_fullStr | Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
title_full_unstemmed | Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
title_short | Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
title_sort | plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476218/ https://www.ncbi.nlm.nih.gov/pubmed/26157710 |
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