Cargando…

Hypoxic Conditioning as a New Therapeutic Modality

Preconditioning refers to a procedure by which a single noxious stimulus below the threshold of damage is applied to the tissue in order to increase resistance to the same or even different noxious stimuli given above the threshold of damage. Hypoxic preconditioning relies on complex and active defe...

Descripción completa

Detalles Bibliográficos
Autores principales: Verges, Samuel, Chacaroun, Samarmar, Godin-Ribuot, Diane, Baillieul, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476260/
https://www.ncbi.nlm.nih.gov/pubmed/26157787
http://dx.doi.org/10.3389/fped.2015.00058
_version_ 1782377578985684992
author Verges, Samuel
Chacaroun, Samarmar
Godin-Ribuot, Diane
Baillieul, Sébastien
author_facet Verges, Samuel
Chacaroun, Samarmar
Godin-Ribuot, Diane
Baillieul, Sébastien
author_sort Verges, Samuel
collection PubMed
description Preconditioning refers to a procedure by which a single noxious stimulus below the threshold of damage is applied to the tissue in order to increase resistance to the same or even different noxious stimuli given above the threshold of damage. Hypoxic preconditioning relies on complex and active defenses that organisms have developed to counter the adverse consequences of oxygen deprivation. The protection it confers against ischemic attack for instance as well as the underlying biological mechanisms have been extensively investigated in animal models. Based on these data, hypoxic conditioning (consisting in recurrent exposure to hypoxia) has been suggested a potential non-pharmacological therapeutic intervention to enhance some physiological functions in individuals in whom acute or chronic pathological events are anticipated or existing. In addition to healthy subjects, some benefits have been reported in patients with cardiovascular and pulmonary diseases as well as in overweight and obese individuals. Hypoxic conditioning consisting in sessions of intermittent exposure to moderate hypoxia repeated over several weeks may induce hematological, vascular, metabolic, and neurological effects. This review addresses the existing evidence regarding the use of hypoxic conditioning as a potential therapeutic modality, and emphasizes on many remaining issues to clarify and future researches to be performed in the field.
format Online
Article
Text
id pubmed-4476260
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-44762602015-07-08 Hypoxic Conditioning as a New Therapeutic Modality Verges, Samuel Chacaroun, Samarmar Godin-Ribuot, Diane Baillieul, Sébastien Front Pediatr Pediatrics Preconditioning refers to a procedure by which a single noxious stimulus below the threshold of damage is applied to the tissue in order to increase resistance to the same or even different noxious stimuli given above the threshold of damage. Hypoxic preconditioning relies on complex and active defenses that organisms have developed to counter the adverse consequences of oxygen deprivation. The protection it confers against ischemic attack for instance as well as the underlying biological mechanisms have been extensively investigated in animal models. Based on these data, hypoxic conditioning (consisting in recurrent exposure to hypoxia) has been suggested a potential non-pharmacological therapeutic intervention to enhance some physiological functions in individuals in whom acute or chronic pathological events are anticipated or existing. In addition to healthy subjects, some benefits have been reported in patients with cardiovascular and pulmonary diseases as well as in overweight and obese individuals. Hypoxic conditioning consisting in sessions of intermittent exposure to moderate hypoxia repeated over several weeks may induce hematological, vascular, metabolic, and neurological effects. This review addresses the existing evidence regarding the use of hypoxic conditioning as a potential therapeutic modality, and emphasizes on many remaining issues to clarify and future researches to be performed in the field. Frontiers Media S.A. 2015-06-22 /pmc/articles/PMC4476260/ /pubmed/26157787 http://dx.doi.org/10.3389/fped.2015.00058 Text en Copyright © 2015 Verges, Chacaroun, Godin-Ribuot and Baillieul. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Verges, Samuel
Chacaroun, Samarmar
Godin-Ribuot, Diane
Baillieul, Sébastien
Hypoxic Conditioning as a New Therapeutic Modality
title Hypoxic Conditioning as a New Therapeutic Modality
title_full Hypoxic Conditioning as a New Therapeutic Modality
title_fullStr Hypoxic Conditioning as a New Therapeutic Modality
title_full_unstemmed Hypoxic Conditioning as a New Therapeutic Modality
title_short Hypoxic Conditioning as a New Therapeutic Modality
title_sort hypoxic conditioning as a new therapeutic modality
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476260/
https://www.ncbi.nlm.nih.gov/pubmed/26157787
http://dx.doi.org/10.3389/fped.2015.00058
work_keys_str_mv AT vergessamuel hypoxicconditioningasanewtherapeuticmodality
AT chacarounsamarmar hypoxicconditioningasanewtherapeuticmodality
AT godinribuotdiane hypoxicconditioningasanewtherapeuticmodality
AT baillieulsebastien hypoxicconditioningasanewtherapeuticmodality