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The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ

Brain-derived neurotrophic factor (BDNF) has a crucial role in learning and memory by promoting neuronal survival and modulating synaptic connectivity. BDNF levels are lower in the brains of individuals with Alzheimer's disease (AD), suggesting a pathogenic involvement. The Drosophila orthologu...

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Detalles Bibliográficos
Autores principales:	Lim, Jung Yeon, Reighard, Charles P., Crowther, Damian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476443/ https://www.ncbi.nlm.nih.gov/pubmed/25954034 http://dx.doi.org/10.1093/hmg/ddv130

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