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Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory

Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in adult hippocampal neurogenesis can cause learni...

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Detalles Bibliográficos
Autores principales:	Bonds, Jacqueline A., Kuttner-Hirshler, Yafit, Bartolotti, Nancy, Tobin, Matthew K., Pizzi, Michael, Marr, Robert, Lazarov, Orly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476567/ https://www.ncbi.nlm.nih.gov/pubmed/26098332 http://dx.doi.org/10.1371/journal.pone.0131266

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