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Translating Alcohol Research: Opportunities and Challenges
Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms u...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute on Alcohol Abuse and Alcoholism
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476605/ https://www.ncbi.nlm.nih.gov/pubmed/26259085 |
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author | Batman, Angela M. Miles, Michael F. |
author_facet | Batman, Angela M. Miles, Michael F. |
author_sort | Batman, Angela M. |
collection | PubMed |
description | Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of streamlining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD. |
format | Online Article Text |
id | pubmed-4476605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | National Institute on Alcohol Abuse and Alcoholism |
record_format | MEDLINE/PubMed |
spelling | pubmed-44766052015-06-24 Translating Alcohol Research: Opportunities and Challenges Batman, Angela M. Miles, Michael F. Alcohol Res Feature Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of streamlining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD. National Institute on Alcohol Abuse and Alcoholism 2015 /pmc/articles/PMC4476605/ /pubmed/26259085 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated. |
spellingShingle | Feature Batman, Angela M. Miles, Michael F. Translating Alcohol Research: Opportunities and Challenges |
title | Translating Alcohol Research: Opportunities and Challenges |
title_full | Translating Alcohol Research: Opportunities and Challenges |
title_fullStr | Translating Alcohol Research: Opportunities and Challenges |
title_full_unstemmed | Translating Alcohol Research: Opportunities and Challenges |
title_short | Translating Alcohol Research: Opportunities and Challenges |
title_sort | translating alcohol research: opportunities and challenges |
topic | Feature |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476605/ https://www.ncbi.nlm.nih.gov/pubmed/26259085 |
work_keys_str_mv | AT batmanangelam translatingalcoholresearchopportunitiesandchallenges AT milesmichaelf translatingalcoholresearchopportunitiesandchallenges |