A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

Mycobacterium tuberculosis (Mtb) is well-established to be one of the most important bacterial pathogens for which new antimicrobial therapies are needed. Herein, we describe the development of a high throughput screening assay for the identification of molecules that are bactericidal against Mycoba...

Descripción completa

Detalles Bibliográficos
Autores principales: Forbes, Lauren, Ebsworth-Mojica, Katherine, DiDone, Louis, Li, Shao-Gang, Freundlich, Joel S., Connell, Nancy, Dunman, Paul M., Krysan, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476654/
https://www.ncbi.nlm.nih.gov/pubmed/26098625
http://dx.doi.org/10.1371/journal.pone.0129234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476654/
https://www.ncbi.nlm.nih.gov/pubmed/26098625
http://dx.doi.org/10.1371/journal.pone.0129234

Ejemplares similares